Evidence map›Paper›PMID 31925860›Full record

ArticleFASEB journal : official publication of the Federation of American Societies for Experimental Biology2020

Knee loading repairs osteoporotic osteoarthritis by relieving abnormal remodeling of subchondral bone via Wnt/β-catenin signaling.

Weiwei Zheng, Beibei Ding, Xinle Li, Daquan Liu, Hiroki Yokota, Ping Zhang

Open access · bronzeAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in FASEB journal : official publication of the Federation of American Societies for Experimental Biology, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 24 papers.

0numbers the graph read from it
0cells of the map it votes in
24citing papers in PubMed
3.7field-weighted citation impact, top 6% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

24 citing papers in PubMed, 41 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 2 institutions in 2 countries.

Weiwei ZhengDepartment of Anatomy and Histology, School of Basic Medical Sciences, Tianjin Medical University, Tianjin, China.
Beibei DingDepartment of Anatomy and Histology, School of Basic Medical Sciences, Tianjin Medical University, Tianjin, China.
Xinle LiDepartment of Anatomy and Histology, School of Basic Medical Sciences, Tianjin Medical University, Tianjin, China.
Daquan LiuDepartment of Anatomy and Histology, School of Basic Medical Sciences, Tianjin Medical University, Tianjin, China.
Hiroki YokotaDepartment of Biomedical Engineering, Indiana University-Purdue University Indianapolis, IN, USA.
Ping ZhangDepartment of Anatomy and Histology, School of Basic Medical Sciences, Tianjin Medical University, Tianjin, China.
Tianjin Medical University · CNIndiana University – Purdue University Indianapolis · US

Funding

MECHANICAL LOADING AND BONER01AR052144 · NIAMS · INDIANA UNIV-PURDUE UNIV AT INDIANAPOLIS · PI YOKOTA, HIROKI · 2006 to 2018
$4.2M
NIAMS NIH HHS R01 AR052144
6 · The paper itself

Abstract

Osteoporotic osteoarthritis (OPOA) is a common bone disease mostly in the elderly, but the relationship between Osteoporotic (OP) and osteoarthritis (OA) is complex. It has been shown that knee loading can mitigate OA symptoms. However, its effects on OPOA remain unclear. In this study, we characterized pathological linkage of OP to OA, and evaluated the effect of knee loading on OPOA. We employed two mouse models (OA and OPOA), and conducted histology, cytology, and molecular analyses. In the OA and OPOA groups, articular cartilage was degenerated and Osteoarthritis Research Society International score was increased. Subchondral bone underwent abnormal remodeling, the differentiation of bone marrow mesenchymal stem cells (BMSCs) to osteoblasts and chondrocytes was reduced, and migration and adhesion of pre-osteoclasts were enhanced. Compared to the OA group, the pathological changes of OA in the OPOA group were considerably aggravated. After knee loading, however, cartilage degradation was effectively prevented, and the abnormal remodeling of subchondral bone was significantly inhibited. The differentiation of BMSCs was also improved, and the expression of Wnt/β-catenin was elevated. Collectively, this study demonstrates that osteoporosis aggravates OA symptoms. Knee loading restores OPOA by regulating subchondral bone remodeling, and may provide an effective method for repairing OPOA.

Indexed as

Weight-BearingWnt Signaling PathwayAnimalsCartilage, ArticularCell AdhesionCell DifferentiationCell MovementCells, CulturedChondrocytesFemaleHumansMesenchymal Stem CellsMiceOsteoarthritisOsteoblastsOsteoporosis, Postmenopausalknee loadingosteoblastosteoclastosteoporotic osteoarthritisWnt signaling

Identifiers

PMID31925860
PMCPMC7018573
OpenAlexW2999654231

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.