Evidence map›Paper›PMID 31925809›Full record

Trial reportBritish journal of clinical pharmacology2020

Effects of statin therapy and exercise on postprandial triglycerides in overweight individuals with hypercholesterolaemia.

Ricardo Mora-Rodriguez, Juan Fernando Ortega, Felix Morales-Palomo, Miguel Ramirez-Jimenez, Alfonso Moreno-Cabañas

Registry-linked trialOpen access · bronzeAbstract readRandomized Controlled Trial
PubMed Full text at PMC Publisher
In one paragraph

Trial report in British journal of clinical pharmacology, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT04477590 (Optimizing Exercise Training Effects on Metabolic Syndrome Factors by Altering the Timing of Medication and Meal Ingestion), which is not on this map. Cited by 9 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
9citing papers in PubMed, 2 pooled it
2.0field-weighted citation impact, top 13% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT04477590 naunknown statusnot on this mapstarted 2022, after this paper: background citation

Optimizing Exercise Training Effects on Metabolic Syndrome Factors by Altering the Timing of Medication and Meal Ingestion

TypeinterventionalSponsorUniversity of Castilla-La ManchaRan2022 to 2024Enrolled160ConditionsMetabolic Syndrome, Protection Against, Exercise Training, Metformin, StatinsArmsEXERCISE TRAINING WITH OR WITHOUT MEDICATION
3 · Its place in the literature

Who cites it

9 citing papers in PubMed, 2 syntheses or guidelines pooled it, 20 citations in OpenAlex.

  1. Pooled it
  2. Pooled it
  3. Trial
  4. Trial
  5. Review
  6. Article
  7. Review
  8. Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 1 institution in 1 country.

Ricardo Mora-RodriguezExercise Physiology Lab at Toledo, University of Castilla-La Mancha, Spain.ORCID 0000-0001-9252-4933
Juan Fernando OrtegaExercise Physiology Lab at Toledo, University of Castilla-La Mancha, Spain.
Felix Morales-PalomoExercise Physiology Lab at Toledo, University of Castilla-La Mancha, Spain.
Miguel Ramirez-JimenezExercise Physiology Lab at Toledo, University of Castilla-La Mancha, Spain.
Alfonso Moreno-CabañasExercise Physiology Lab at Toledo, University of Castilla-La Mancha, Spain.
University of Castilla-La Mancha · ES

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

aimsTo determine the effects of statins on postprandial lipaemia (PPL) and to study if exercise could enhance statin actions.

methodsTen hypercholesteraemic (blood cholesterol 204 ± 36 mg dL

resultsBefore the fat meal, statin withdrawal (i.e. PLAC and EXER+PLAC) increased blood triglycerides (TG; 24%), low-density lipoprotein-cholesterol (31%) and total cholesterol (19%; all P < .05) evidencing treatment compliance. After the meal, statin withdrawal increased 5-hour postprandial TG (PPTG) compared to its matched trials (94% higher PLAC vs STA and 45% higher EXER+PLAC vs EXER+STA; P < .05). EXER+PLAC trial did not lower PPTG below PLAC (i.e. incremental AUC of 609 ± 152 vs 826 ± 190 mg dL

conclusionIn hypercholesteraemic metabolic syndrome individuals, chronic statin therapy blunts the elevations in TG after a fat meal (i.e. incremental area under the curve of PPTG) reducing the cardiovascular risk associated to their atherogenic dyslipidaemia. However, a single bout of intense aerobic exercise before the high fat meal, does not reduce PPTG but also does not interfere with the effects of statin treatment.

Indexed as

Hydroxymethylglutaryl-CoA Reductase InhibitorsHypercholesterolemiaHyperlipidemiasExerciseHumansOverweightTriglyceridesHydroxymethylglutaryl-CoA Reductase InhibitorsTriglyceridesaerobic exercisehydroxymethylglutaryl-CoA reductase inhibitorhypercholesterolaemiametabolic syndrome Xpostprandial lipaemia

Identifiers

PMID31925809
PMCPMC7256119
OpenAlexW2999200941

What OpenQuestion holds

Texttitle and abstract
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.