ArticleBiological trace element research2020
Selenium Deficiency in Chickens Induces Intestinal Mucosal Injury by Affecting the Mucosa Morphology, SIgA Secretion, and GSH-Px Activity.
Article in Biological trace element research, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 28 papers, 1 of them a synthesis that pooled it.
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Who cites it
28 citing papers in PubMed, 1 synthesis or guideline pooled it, 38 citations in OpenAlex.
- A Meta-analysis of Optimum Level of Dietary Nanoselenium on Performances, Blood Constituents, Antioxidant Activity, Carcass, and Giblet Weight of Broiler Chickens.Biological trace element research · 2024Pooled it
- Applications of Nano-Selenium in the Poultry Industry: An Overview.Nanomaterials (Basel, Switzerland) · 2026Review
- Selenium-enriched yeast improves gut health in broilers by modulating the gut microbiota-metabolites-intestinal mucosal immunity axis.Journal of animal science · 2026Article
- Multi-omics analysis revealed coordinated responses of rumen microbiota and epithelium of goats to dietary supplementation of glucosamine selenium.Animal nutrition (Zhongguo xu mu shou yi xue hui) · 2025Article
- Effect of Nano-Selenium on Intestinal Oxidative Stress Induced by HAntioxidants (Basel, Switzerland) · 2025Article
- Effect of selenium nanoparticles on intestinal immunity through regulation of NLRP3 signaling pathway.Scientific reports · 2025Article
- Dietary supplementation with isochlorogenic acid improves growth performance and intestinal health of broilers.Animal nutrition (Zhongguo xu mu shou yi xue hui) · 2025Article
- Dose-dependent effects of capsaicin on intestinal morphology and microbiota composition in mice: Structural, immunohistochemical, and microbial insights.Veterinary world · 2025Article
- Selenium deficiency modulates necroptosis-mediated intestinal inflammation in broiler through the lncRNAWSF27/miRNA1696/GPX3 axis.Journal of animal science · 2025Article
- Dietary selenium supplementation: its impact on growth, microbiota, antioxidant capacity, and immunity in Inner Mongolian cashmere goats.Frontiers in veterinary science · 2025Article
- Effects ofFrontiers in veterinary science · 2025Article
- Biogenic Selenium Nanoparticles Synthesized by L. brevis 23017 Enhance Aluminum Adjuvanticity and Make Up for its Disadvantage in Mice.Biological trace element research · 2024Article
- Effect of Nano-selenium on Biological Mechanism of Goblet Cells of the Small Intestine Within Laying Hen.Biological trace element research · 2024Article
- Effects of selenoprotein extracts fromFrontiers in immunology · 2024Article
- Selenium deficiency-induced multiple tissue damage with dysregulation of immune and redox homeostasis in broiler chicks under heat stress.Science China. Life sciences · 2023Article
- Selenium Deficiency Induces Inflammatory Response and Decreased Antimicrobial Peptide Expression in Chicken Jejunum Through Oxidative Stress.Biological trace element research · 2023Article
- Selenium deficiency increased duodenal permeability and decreased expression of antimicrobial peptides by activating ROS/NF-κB signal pathway in chickens.Biometals : an international journal on the role of metal ions in biology, biochemistry, and medicine · 2023Article
- Nano selenium-enriched probioticFrontiers in immunology · 2023Article
- Protective role of Cecropin AD against LPS-induced intestinal mucosal injury in chickens.Frontiers in immunology · 2023Article
- Alleviating Effect of Methionine on Intestinal Development and Intercellular Junction Induced by Nickel.Biological trace element research · 2022Article
Corrections and comments
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Authors and funding
7 authors at 1 institution in 1 country.
Funding
Abstract
The small intestine is one of the target organs of dietary selenium (Se) deficiency. Our objective was to investigate the effects of Se deficiency on small intestinal mucosa morphology and function in chickens. In the present study, 1-day (d)-old chickens were fed either a commercial diet with 0.15 mg/kg Se (control group) or a Se-deficient diet with 0.016 mg/kg Se (Se-group). The average daily weight gain, Se content in the blood, secretory immunoglobulin A (SIgA) secretion, and glutathione peroxidase (GSH-Px) activity in the small intestine in chickens were examined after 10, 20, 30, and 40 days of feeding. We also observed the morphology of the small intestine and recorded the number of intraepithelial lymphocytes (IELs). The average daily weight gain decreased; the level of Se in the blood decreased significantly; and SIgA secretion and GSH-Px activity in the duodenum, jejunum, and ileum decreased to different degrees. Histological analysis showed that the villus length, crypt depth, mucosal thickness, and number of IELs in the small intestine decreased to different extents in different periods. In the Se-group, longer feeding times were associated with more severe injury to physiological structure and function in the intestinal mucosa in chickens. In conclusion, Se deficiency induced injury of the mucosal immune barrier and physical barrier of the small intestine, and decreased the growth performance and antioxidant capacity in chickens.
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