ArticleEnvironmental science and pollution research international2020
Cross-sectional study to identify risk factors associated with the occurrence of antimicrobial resistance genes in honey bees Apis mellifera) in Umbria, Central Italy.
Article in Environmental science and pollution research international, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.
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Who cites it
7 citing papers in PubMed, 22 citations in OpenAlex.
- Antimicrobial Resistance Genes (ARGs) Monitoring and Gut Microbiota Profiling in Honey Bees from an Intensive Livestock Farming Area in Northwestern Italy.Microorganisms · 2026Article
- Applying Artificial Neural Networks to Oxidative Stress Biomarkers in Forager Honey Bees (Toxics · 2023Article
- Antimicrobial-Resistant Environmental Bacteria Isolated Using a Network of Honey Bee Colonies (Transboundary and emerging diseases · 2023Article
- Estimating the Rates of Acquisition and loss of Resistance ofMicroorganisms · 2021Article
- Honeybee Exposure to Veterinary Drugs: How Is the Gut Microbiota Affected?Microbiology spectrum · 2021Article
- Insects, Rodents, and Pets as Reservoirs, Vectors, and Sentinels of Antimicrobial Resistance.Antibiotics (Basel, Switzerland) · 2021Review
- Comparative study of toxic heavy metal residues and other properties of honey from different environmental production systems.Environmental science and pollution research international · 2020Article
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Authors and funding
12 authors at 2 institutions in 2 countries.
Funding
Abstract
The use antimicrobials for therapeutic and metaphylactic purpose in humans and agriculture exerts selective pressure on animal and environmental microbiota resulting in the survival and spread of antimicrobial resistance genes among bacteria and subsequent development of resistance in bacteria. Previous studies have shown that honey bees' microbiota (Apis mellifera) can accumulate antimicrobial resistance genes in their microbiome and act as collectors and disseminators of resistance genes. The aim of this study was to investigate to what extent honey bees act as reservoir of select antimicrobial resistance genes. This study was conducted on 35 groups of bees. Bees were collected from 35 sites in Umbria, Italy. PCR was used to screen pooled ground bees' specimens for genes that code for resistance against antimicrobials that are commonly used in humans and in veterinary medicine including aminoglycosides (aph), beta-lactams (blaZ), tetracycline (tetM) and sulphonamides (sul1 and sul2). Twenty-four samples out of 35 (68.57%) were positive for at least one antimicrobial resistance gene. Two samples were positive for the aph, 5.71%; eight for blaZ, 22.86%; three for tetM, 8.57%; ten for sul1, 28.57% and eighteen for sul2, 51.43%. Positivity to more than one antimicrobial resistance gene was observed in nine samples, 25.71%. The multivariate analysis identified "presence of farms nearby" as the factor most closely related to PCR positivity. Honey bees (Apis mellifera) from Umbria, Italy, carry antimicrobial resistance genes and can be used as indicators of the presence of resistance genes in the environment.
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