Evidence map›Paper›PMID 31925659›Full record

ArticleInternational ophthalmology2020

Association between CFH single nucleotide polymorphisms and response to photodynamic therapy in patients with central serous chorioretinopathy.

Dandan Linghu, Hui Xu, Zhiqiao Liang, Tingting Gao, Zhaojun Lin, Xiaoxin Li, Lvzhen Huang, Mingwei Zhao

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Article in International ophthalmology, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

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1citing papers in PubMed
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1 · What the graph read from it

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3 · Its place in the literature

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1 citing paper in PubMed.

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4 · The record

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5 · Who and what money

Authors and funding

8 authors.

Dandan LinghuDepartment of Ophthalmology, Peking University People's Hospital, Xizhimen South Street No. 11, Beijing, 100044, China.
Hui XuDepartment of Ophthalmology, Peking University People's Hospital, Xizhimen South Street No. 11, Beijing, 100044, China.
Zhiqiao LiangDepartment of Ophthalmology, Peking University People's Hospital, Xizhimen South Street No. 11, Beijing, 100044, China.
Tingting GaoDepartment of Ophthalmology, Peking University People's Hospital, Xizhimen South Street No. 11, Beijing, 100044, China.
Zhaojun LinDepartment of Ophthalmology, Peking University People's Hospital, Xizhimen South Street No. 11, Beijing, 100044, China.
Xiaoxin LiDepartment of Ophthalmology, Peking University People's Hospital, Xizhimen South Street No. 11, Beijing, 100044, China.
Lvzhen HuangDepartment of Ophthalmology, Peking University People's Hospital, Xizhimen South Street No. 11, Beijing, 100044, China.
Mingwei ZhaoDepartment of Ophthalmology, Peking University People's Hospital, Xizhimen South Street No. 11, Beijing, 100044, China. rmykzmw@sina.com.

Funding

National key research and development program 2016YFC0904801National key research and development program 2017YFC0111204National Natural Science Foundation of China Grant 81470651National Natural Science Foundation of China Grant 81770943Research Fund for Science and Technology Program of Beijing Z161100000516037Research Fund for Science and Technology Program of Beijing Z171100002217081
6 · The paper itself

Abstract

purposeTo evaluate the association between single nucleotide polymorphisms (SNPs) in the complement factor H (CFH) gene and response to PDT in patients with CSC.

methods103 eyes from 93 patients with CSC were enrolled from Department of Ophthalmology of the People's Hospital Peking University. Genotyping for selected SNPs in the CFH gene was performed, and multivariate linear analysis was used to identify factors influencing PDT treatment outcomes. Genetics associations between SNPs in the CFH gene and response to PDT in patients with CSC were analyzed.

resultsNone of the seven SNPs examined in this study (rs800292, rs1061170, rs3753394, rs3753396, rs2284664, rs1329428, and rs1065489) showed significant associations with 1-month outcomes after PDT in patients with CSC (P > 0.05). Baseline BCVA changed at 1 month after PDT (P < 0.001), and baseline retinal thickness was associated with changes in retinal thickness at 1 month after PDT (P < 0.001). Age was significantly associated with resolution of SRF at 1 month after PDT (P = 0.004).

conclusionsThere were no significant associations between SNPs in the CFH gene and 1-month outcomes after PDT in patients with CSC. However, baseline BCVA, baseline retinal thickness, and age were significantly associated with response to PDT in patients with CSC. Larger studies with more power are necessary to further determine whether an association exists between SNPs in the CFH gene and PDT in patients with CSC.

Indexed as

Polymorphism, Single NucleotideVisual AcuityCentral Serous ChorioretinopathyComplement Factor HDNAFemaleFluorescein AngiographyFollow-Up StudiesFundus OculiHumansMaleMiddle AgedPhotochemotherapyPhotosensitizing AgentsRetrospective StudiesTomography, Optical CoherenceComplement Factor HDNAPhotosensitizing AgentsVerteporfinCentral serous chorioretinopathyComplement factor HSingle nucleotide polymorphismsVerteporfin photodynamic therapy

Identifiers

PMID31925659

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.