Evidence map›Paper›PMID 31925653›Full record

ArticleJournal of fluorescence2020

Modulated Protein Binding Ability of Anti-Diabetic Drugs in Presence of Monodispersed Gold Nanoparticles and its Inhibitory Potential towards Advanced Glycated End (AGE) Product Formation.

Imocha Rajkumar Singh, Sivaprasad Mitra

Abstract read
PubMed Publisher
In one paragraph

Article in Journal of fluorescence, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
0.4field-weighted citation impact, top 41% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed, 6 citations in OpenAlex.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors at 1 institution in 1 country.

Imocha Rajkumar SinghCentre for Advanced Studies, Department of Chemistry, North-Eastern Hill University, Shillong, 793 022, India.
Sivaprasad MitraCentre for Advanced Studies, Department of Chemistry, North-Eastern Hill University, Shillong, 793 022, India. smitra@nehu.ac.in.ORCID http://orcid.org/0000-0002-5746-0070
North Eastern Hill University · IN

Funding

Science and Engineering Research Board SR/FST/CSI-194/2008
6 · The paper itself

Abstract

Binding strength of the anti-diabetic drugs chlorpropamide (CPM) and tolbutamide (TBM) with model protein bovine serum albumin (BSA) shows strong modulation in presence of colloidal gold nanoparticles (AuNP). Intrinsic tryptophan fluorescence of both the native BSA and BSA-AuNP conjugate quenched in presence of the drugs. Stern-Volmer quenching constant (K

Indexed as

AdsorptionAnimalsBinding SitesCattleChlorpropamideColloidsGlycation End Products, AdvancedGoldHydrophobic and Hydrophilic InteractionsHypoglycemic AgentsMetal NanoparticlesParticle SizeSerum Albumin, BovineSpectrometry, FluorescenceSurface PropertiesTemperatureChlorpropamideColloidsGlycation End Products, AdvancedGoldHypoglycemic AgentsSerum Albumin, BovineTolbutamideAGE productDrug bindingFluorescenceNanomedicineSerum albumin

Identifiers

PMID31925653
OpenAlexW3000649320

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.