Evidence map›Paper›PMID 31925587›Full record

ArticleClinical oral investigations2020

Bone union formation in the rat mandibular symphysis using hydroxyapatite with or without simvastatin: effects on healthy, diabetic, and osteoporotic rats.

F Camacho-Alonso, C Martínez-Ortiz, L Plazas-Buendía, A M Mercado-Díaz, C Vilaplana-Vivo, J A Navarro, A J Buendía, J J Merino, Y Martínez-Beneyto

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Article in Clinical oral investigations, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
1.1field-weighted citation impact, top 28% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed, 11 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 3 institutions in 1 country.

F Camacho-AlonsoDepartment of Oral Surgery, University of Murcia, Murcia, Spain. fcamacho@um.es.ORCID http://orcid.org/0000-0002-3739-1792
C Martínez-OrtizIn private dental practice, Murcia, Spain.
L Plazas-BuendíaIn private dental practice, Murcia, Spain.
A M Mercado-DíazIn private dental practice, Murcia, Spain.
C Vilaplana-VivoDepartment of Oral Surgery, University of Murcia, Murcia, Spain.
J A NavarroDepartment of Histology and Pathological Anatomy, University of Murcia, Murcia, Spain.
A J BuendíaDepartment of Histology and Pathological Anatomy, University of Murcia, Murcia, Spain.
J J MerinoDepartment of Biochemistry and Molecular Biology, Complutense University of Madrid, Madrid, Spain.
Y Martínez-BeneytoDepartment of Preventive and Community Dentistry, University of Murcia, Murcia, Spain.
Universidad de Murcia · ESIVI Murcia Clinic · ESUniversidad Complutense de Madrid · ES

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

objectiveThe objective is to compare new bone formation in critical defects in healthy, diabetic, and osteoporotic rats filled with hydroxyapatite (HA) alone and HA combined with simvastatin (SV). MATERIALS AND

methodsA total of 48 adult female Sprague-Dawley rats were randomized into three groups (n = 16 per group): Group, 1 healthy; Group 2, diabetics; and Group 3, osteoporotics. Streptozotocin was used to induce type 1 diabetes in Group 2, while bilateral ovariectomy was used to induce osteoporosis in Group 3. The central portion of the rat mandibular symphysis was used as a physiological critical bone defect. In each group, eight defects were filled with HA alone and eight with HA combined with SV. The animals were sacrificed at 4 and 8 weeks, and the mandibles were processed for micro-computed tomography to analyze radiological union and bone mineral density (BMD); histological analysis of the bone union; and immunohistochemical analysis, which included immunoreactivity of vascular endothelial growth factor (VEGF) and bone morphogenetic protein 2 (BMP-2).

resultsIn all groups (healthy, diabetics, and osteoporotics), the defects filled with HA + SV presented greater radiological bone union, BMD, histological bone union, and more VEGF and BMP-2 positivity, in comparison with bone defects treated with HA alone.

conclusionsCombined application of HA and SV improves bone regeneration in mandibular critical bone defects compared with application of HA alone in healthy, diabetic, and osteoporotic rats. CLINICAL RELEVANCE: This study might help to patients with osteoporosis or uncontrolled diabetes type 1, but future studies should be done.

Indexed as

Bone RegenerationMandibleOsteogenesisAnimalsBone Morphogenetic Protein 2Diabetes Mellitus, ExperimentalDurapatiteFemaleOsteoporosisOvariectomyRandom AllocationRatsRats, Sprague-DawleySimvastatinVascular Endothelial Growth Factor AX-Ray MicrotomographyBmp2 protein, ratBone Morphogenetic Protein 2DurapatiteSimvastatinVascular Endothelial Growth Factor Avascular endothelial growth factor A, ratBone regenerationCritical bone defectDiabetesHydroxyapatiteMandibular symphysisOsteoporosisRatsSimvastatin

Identifiers

PMID31925587
OpenAlexW3000411954

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.