ArticlePflugers Archiv : European journal of physiology2020
Afferent innervation of the ischemic kidney contributes to renal dysfunction in renovascular hypertensive rats.
Article in Pflugers Archiv : European journal of physiology, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 26 papers.
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26 citing papers in PubMed, 47 citations in OpenAlex.
- Article
- Deletion of the TRPV1 channel attenuates afferent renal nerve responses to renal artery occlusion but not elevated renal pelvic pressure.The Journal of physiology · 2026Article
- Effects of intrarenal afferent stimulation by bradykinin on renal sympathetic nerve activity: tonic inhibition contributing to renal function.Pflugers Archiv : European journal of physiology · 2025Article
- Cardiovascular Autonomic Control in Normotensive Patients with Autosomal Dominant Polycystic Kidney Disease.Kidney360 · 2025Article
- Renal nerves and hypertension contribute to impaired proximal tubule megalin-mediated albumin uptake in renovascular hypertensive rats.Hypertension research : official journal of the Japanese Society of Hypertension · 2025Article
- Afferent innervation of the kidney: projections to and processing in the central nervous system.Frontiers in physiology · 2025Review
- 2-Kidney-1-clip hypertension is not attenuated in mice lacking the transient receptor potential vanilloid type 1 (TRPV1) channel.Frontiers in physiology · 2025Article
- Blockade of mesenteric and omental adipose tissue sensory neurons improves cardiac remodeling through sympathetic pathway.iScience · 2024Article
- The Total Denervation of the Ischemic Kidney Induces Differential Responses in Sodium Transporters' Expression in the Contralateral Kidney in Goldblatt Rats.International journal of molecular sciences · 2024Article
- Neuroimmune interplay in kidney health and disease: Role of renal nerves.Autonomic neuroscience : basic & clinical · 2023Review
- Afferent neurons of the kidney with impaired firing pattern in inflammation - role of sodium currents?Pflugers Archiv : European journal of physiology · 2023Article
- Renal and hypothalamic inflammation in renovascular hypertension: role of afferent renal nerves.American journal of physiology. Regulatory, integrative and comparative physiology · 2023Article
- Deletion of the Transient Receptor Potential Vanilloid 1 Channel Attenuates Sympathoexcitation and Hypertension and Improves Glomerular Filtration Rate in 2-Kidney-1-Clip Rats.Hypertension (Dallas, Tex. : 1979) · 2023Article
- A kidney-brain neural circuit drives progressive kidney damage and heart failure.Signal transduction and targeted therapy · 2023Article
- Neural and central mechanisms of kidney fibrosis after relief of ureteral obstruction.iScience · 2023Article
- Impact of Selective Renal Afferent Denervation on Oxidative Stress and Vascular Remodeling in Spontaneously Hypertensive Rats.Antioxidants (Basel, Switzerland) · 2022Article
- Cardiorenal Syndrome: The Role of Neural Connections Between the Heart and the Kidneys.Circulation research · 2022Review
- Article
- Renal Nerve Ablation in Nephritis and Beyond.Journal of the American Society of Nephrology : JASN · 2021Article
- Responsiveness of afferent renal nerve units in renovascular hypertension in rats.Pflugers Archiv : European journal of physiology · 2021Article
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12 authors at 3 institutions in 1 country.
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Abstract
The ablation of renal nerves, by destroying both the sympathetic and afferent fibers, has been shown to be effective in lowering blood pressure in resistant hypertensive patients. However, experimental studies have reported that the removal of sympathetic fibers may lead to side effects, such as the impairment of compensatory cardiorenal responses during a hemodynamic challenge. In the present study, we evaluated the effects of the selective removal of renal afferent fibers on arterial hypertension, renal sympathetic nerve activity, and renal changes in a model of renovascular hypertension. After 4 weeks of clipping the left renal artery, afferent renal denervation (ARD) was performed by exposing the left renal nerve to a 33 mM capsaicin solution for 15 min. After 2 weeks of ARD, we found reduced MAP (~ 18%) and sympathoexcitation to both the ischemic and contralateral kidneys in the hypertensive group. Moreover, a reduction in reactive oxygen species was observed in the ischemic (76%) and contralateral (27%) kidneys in the 2K1C group. In addition, ARD normalized renal function markers and proteinuria and podocin in the contralateral kidney. Taken altogether, we show that the selective removal of afferent fibers is an effective method to reduce MAP and improve renal changes without compromising the function of renal sympathetic fibers in the 2K1C model. Renal afferent nerves may be a new target in neurogenic hypertension and renal dysfunction.
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