ArticleCurrent microbiology2020
Bacillus Strains Associated to Homoscleromorpha Sponges are Highly Active Against Multidrug Resistant Bacteria.
Article in Current microbiology, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.
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Who cites it
11 citing papers in PubMed.
- Quorum Sensing Inhibition by Sponge-AssociatedAntibiotics (Basel, Switzerland) · 2025Article
- Impact of growth conditions on the abundance and diversity of cultivable bacteria recovered fromFEMS microbes · 2025Article
- Functional and Genomic Insights into the Biotechnological Potential of Vibrio spp. Isolated from Deeply Polluted and Pristine Environments.Current microbiology · 2024Article
- Microbial richness and air chemistry in aerosols above the PBL confirm 2,000-km long-distance transport of potential human pathogens.Proceedings of the National Academy of Sciences of the United States of America · 2024Article
- Antibacterial activity of soil-isolatedAfrican journal of laboratory medicine · 2023Article
- Homoscleromorpha-derived Bacillus spp. as potential sources of biotechnologically-relevant hydrolases and biosurfactants.World journal of microbiology & biotechnology · 2022Article
- Efficacy of Ciprofloxacin and Amoxicillin Removal and the Effect on the Biochemical Composition ofBioengineering (Basel, Switzerland) · 2022Article
- Antibiotic and Heavy Metal Susceptibility of Non-CholeraAntibiotics (Basel, Switzerland) · 2021Article
- Marine Bacterial Secondary Metabolites: A Treasure House for Structurally Unique and Effective Antimicrobial Compounds.Marine drugs · 2021Review
- Not That Close to Mommy: Horizontal Transmission Seeds the Microbiome Associated with the Marine SpongeMicroorganisms · 2020Article
- Peeling the Layers Away: The Genomic Characterization ofFrontiers in microbiology · 2020Article
Corrections and comments
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Authors and funding
4 authors.
Funding
Abstract
The search for new, powerful antimicrobials is essential to respond to the current worldwide spread of antibiotic-resistant pathogens. Sponge-associated bacteria have great potential for production of antimicrobials against resistant and multidrug resistant (MDR) pathogenic bacteria, but only few species of the Class Homoscleromorpha have been screened for these activities so far. The aim of this study was to isolate and identify sponge-associated bacteria active against antibiotic-resistant pathogens from sponges of classes Homoscleromorpha and Demospongiae. By employing five different growth conditions, a total of 239 colony-forming units were isolated and remained viable. Among these, 17 (7.1%) isolates presented antimicrobial activity against pathogenic and (multi)drug resistant bacteria including vancomycin-resistant Enterococcus faecalis, Escherichia coli, Citrobacter freundii, Klebsiella penumoniae, Staphylococcus spp. and Streptococcus spp. Bioactive bacteria belonging to genera Bacillus and Vibrio were identified at species level and the DNA fingerprint patterns showed that strains of the same genus were not clonally related. The most active strains belong to genus Bacillus and were isolated from Oscarella sp., Plakina cyanorosea and Chondrilla caribensis. Our results show for the first time that sponge-associated strains of Bacillus pumilus and Bacillus muralis have high anti-MDR activity, and that the Homoscleromorpha may be a better source of such anti-MDR active bacteria than the Demospongiae. These results suggest that marine bacteria associated to homoscleromorph sponges may be an interesting source of new antimicrobial substances with biotechnological potential to treat infections caused by antibiotic-resistant bacteria.
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Registered trials
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