ReviewApplied microbiology and biotechnology2020
Naproxen in the environment: its occurrence, toxicity to nontarget organisms and biodegradation.
Review in Applied microbiology and biotechnology, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 36 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
36 citing papers in PubMed, 165 citations in OpenAlex.
- Review
- Structural and Functional Changes in Biological Systems of Wastewater Treatment Plants Induced by Bicyclic Non-Steroidal Anti-Inflammatory Drugs-A Review.Molecules (Basel, Switzerland) · 2026Review
- Rapid Eukaryotic Impedimetric Biosensing of Naproxen and Isoniazid: A Proof-of-Concept for Acute Toxicity Monitoring.Biosensors · 2026Article
- Naproxen as an emerging environmental contaminant: Microbial degradation mechanism and optimization strategies.Biodegradation · 2026Review
- Occurrence of anticancer drugs and widely used pharmaceuticals in sewage sludge, compost, and river sediment.Environmental science and pollution research international · 2026Article
- In Silico, In Vitro, and In Vivo Antinociceptive Potential of S-Naproxen Derivatives.ChemistryOpen · 2026Article
- Synthesis and binding studies of two new coumarin-squaramide-based receptors for NSAIDs.RSC advances · 2026Article
- Biodegradation of paracetamol by Amycolatopsis sp. Poz 14.BMC research notes · 2025Article
- Pharmaceutical Contaminants Occurrence and Ecological Risk Assessment Along the Romanian Black Sea Coast.Toxics · 2025Article
- Carbon-Halloysite Nanocomposites and Their Adsorption Characteristics for Pharmaceuticals-A Naproxen Case Study.Materials (Basel, Switzerland) · 2025Article
- The Potential Role of Ecotoxicological Data in National Essential Medicine Lists: A Cross-Sectional Analysis.International journal of environmental research and public health · 2025Article
- Advances in electrochemical sensors for naproxen detection: Mechanisms, performance factors, and emerging challenges.Heliyon · 2025Review
- Article
- Visible-Light-Induced Photocatalytic Degradation of Naproxen Using 5% Cu/TiOMolecules (Basel, Switzerland) · 2024Article
- From prescription to pollution: The ecological consequences of NSAIDs in aquatic ecosystems.Toxicology reports · 2024Review
- Pharmaceutical Pollutants: Ecotoxicological Impacts and the Use of Agro-Industrial Waste for Their Removal from Aquatic Environments.Journal of xenobiotics · 2024Review
- Laccases as Effective Tools in the Removal of Pharmaceutical Products from Aquatic Systems.Life (Basel, Switzerland) · 2024Review
- Microbial degradation of contaminants of emerging concern: metabolic, genetic and omics insights for enhanced bioremediation.Frontiers in bioengineering and biotechnology · 2024Review
- Molecular Dynamics Simulation Prediction of the Partitioning Constants (Environmental science & technology · 2023Article
- Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
2 authors at 1 institution in 1 country.
Funding
Abstract
This article summarizes the current knowledge about the presence of naproxen in the environment, its toxicity to nontarget organisms and the microbial degradation of this drug. Currently, naproxen has been detected in all types of water, including drinking water and groundwater. The concentrations that have been observed ranged from ng/L to μg/L. These concentrations, although low, may have a negative effect of long-term exposure on nontarget organisms, especially when naproxen is mixed with other drugs. The biological decomposition of naproxen is performed by fungi, algae and bacteria, but the only well-described pathway for its complete degradation is the degradation of naproxen by Bacillus thuringiensis B1(2015b). The key intermediates that appear during the degradation of naproxen by this strain are O-desmethylnaproxen and salicylate. This latter is then cleaved by 1,2-salicylate dioxygenase or is hydroxylated to gentisate or catechol. These intermediates can be cleaved by the appropriate dioxygenases, and the resulting products are incorporated into the central metabolism. KEY POINTS: •High consumption of naproxen is reflected in its presence in the environment. •Prolonged exposure of nontargeted organisms to naproxen can cause adverse effects. •Naproxen biodegradation occurs mainly through desmethylnaproxen as a key intermediate.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.