Evidence map›Paper›PMID 31925468›Full record

ArticleNeuroradiology2020

Tumor T2 signal intensity and stalk angulation correlates with endocrine status in pituitary adenoma patients: a quantitative 7 tesla MRI study.

John W Rutland, Puneet Pawha, Puneet Belani, Bradley N Delman, Corey M Gill, Teresa Brown, Khadeen Cheesman, Raj K Shrivastava, Priti Balchandani

Open access · greenAbstract read
In one paragraph

Article in Neuroradiology, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.

0numbers the graph read from it
0cells of the map it votes in
11citing papers in PubMed
1.4field-weighted citation impact, top 18% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

11 citing papers in PubMed, 17 citations in OpenAlex.

  1. Review
  2. Article
  3. Review
  4. Article
  5. Article
  6. Article
  7. Article
  8. Article
  9. Article
  10. Article
  11. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 2 institutions in 1 country.

John W RutlandTranslational and Molecular Imaging Institute, Icahn School of Medicine at Mount Sinai, New York, NY, USA. jack.rutland@icahn.mssm.edu.ORCID http://orcid.org/0000-0002-6412-6708
Puneet PawhaDepartment of Radiology, Icahn School of Medicine at Mount Sinai, New York, NY, USA.
Puneet BelaniDepartment of Radiology, Icahn School of Medicine at Mount Sinai, New York, NY, USA.
Bradley N DelmanTranslational and Molecular Imaging Institute, Icahn School of Medicine at Mount Sinai, New York, NY, USA.
Corey M GillDepartment of Neurosurgery, Icahn School of Medicine at Mount Sinai, 1470 Madison Avenue, Floor 1, New York, NY, 10129, USA.
Teresa BrownDepartment of Medicine, Division of Endocrinology, Diabetes and Bone Diseases, Icahn School of Medicine at Mount Sinai, New York, NY, USA.
Khadeen CheesmanDepartment of Medicine, Division of Endocrinology, Diabetes and Bone Diseases, Icahn School of Medicine at Mount Sinai, New York, NY, USA.
Raj K ShrivastavaDepartment of Neurosurgery, Icahn School of Medicine at Mount Sinai, 1470 Madison Avenue, Floor 1, New York, NY, 10129, USA.
Priti BalchandaniTranslational and Molecular Imaging Institute, Icahn School of Medicine at Mount Sinai, New York, NY, USA.
Icahn School of Medicine at Mount Sinai · USImaging Center · US

Funding

7T Neurosurgical Mapping Protocol for Endoscopic Resection of Skull Base TumorsR01CA202911 · NCI · ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI · PI BALCHANDANI, PRITI · 2016 to 2020
$2.1M
National Institues for Health NIH R01 CA202911NCI NIH HHS R01 CA202911
6 · The paper itself

Abstract

purposePituitary adenomas are common CNS tumors that can cause endocrine dysfunction due to hormone oversecretion and by mass effect on the normal gland. The study of pituitary adenomas and adjacent sellar anatomy with high-resolution 7 T MRI may further characterize endocrine dysfunction. The purpose of this study was to determine the efficacy of 7 T MRI in identifying radiological markers for endocrine function.

methodsMR images obtained in 23 patients with pituitary adenomas were reviewed by consensus between three neuroradiologists. Landmarks and criteria were devised to measure radiological features of stalk, tumor, and normal gland. Fischer's exact tests and nominal logistic regression were performed.

resultsMean cross-sectional area of the stalk just below the infundibular recess was 6.3 ± 3.7 mm

conclusionRadiological characterization of pituitary adenomas and adjacent native pituitary tissue may benefit with the use of 7 T MRI. Corrected T2 SI of tumor may be a sensitive predictor of hormonal secretion and may be useful in the diagnostic work-up for pituitary adenoma. 7 T MRI may be valuable in identifying markers of endocrine function in patients with pituitary adenomas. Our results indicate that hormone-secreting tumors have higher T2-weighted SI and tumors associated with preoperative hypopituitarism have greater stalk curvature angles.

Indexed as

AdenomaFemaleHumansMagnetic Resonance ImagingMaleMiddle AgedPituitary GlandPituitary NeoplasmsProspective StudiesEndocrine abnormalityPituitary adenomaPituitary infundibulumUltrahigh field MRI

Identifiers

PMID31925468
PMCPMC7205143
OpenAlexW3000049114

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.