ArticleCommunications biology2020
The gastrointestinal pathogen Campylobacter jejuni metabolizes sugars with potential help from commensal Bacteroides vulgatus.
Article in Communications biology, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 25 papers.
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Who cites it
25 citing papers in PubMed, 44 citations in OpenAlex.
- Mucin-degrading gut bacteria: context-dependent roles in intestinal homeostasis and disease.Gut microbes · 2026Review
- FucR Functions as a Transcriptional Regulator for L-Fucose Utilization inMicroorganisms · 2025Article
- Growth rates and metabolic traits differ by diarrhoeal manifestation inJournal of medical microbiology · 2025Article
- Article
- Transcriptome analysis of aerotolerant and aerosensitiveFrontiers in microbiology · 2025Article
- Activation of the l-fucose utilization cluster inHeliyon · 2024Article
- Crystal structure of L-2-keto-3-deoxyfuconate 4-dehydrogenase reveals a unique binding mode as a α-furanosyl hemiketal of substrates.Scientific reports · 2024Article
- Gut microbiome dynamics and associations with mortality in critically ill patients.Gut pathogens · 2023Article
- Human gut bacteria tailor extracellular vesicle cargo for the breakdown of diet- and host-derived glycans.Proceedings of the National Academy of Sciences of the United States of America · 2023Article
- Bacterial chemotaxis in human diseases.Trends in microbiology · 2023Review
- Structure and function of microbial α-l-fucosidases: a mini review.Essays in biochemistry · 2023Review
- Transcriptome Analysis of Arcobacter butzleri Infection in a Mucus-Producing Human IntestinalMicrobiology spectrum · 2023Article
- Detection of Bacterial α-l-Fucosidases with anMolecules (Basel, Switzerland) · 2022Article
- Acute infection withFrontiers in cellular and infection microbiology · 2022Article
- Comparative Analysis of L-Fucose Utilization and Its Impact on Growth and Survival ofFrontiers in microbiology · 2022Article
- The evolutionary history ofMicrobial genomics · 2021Article
- Danofloxacin Treatment Alters the Diversity and Resistome Profile of Gut Microbiota in Calves.Microorganisms · 2021Article
- Microbial transformation of the host glycobiome.Glycobiology · 2021Article
- Exploring Changes in the Host Gut Microbiota During a Controlled Human Infection Model forFrontiers in cellular and infection microbiology · 2021Article
- Bacteroides fragilis fucosidases facilitate growth and invasion of Campylobacter jejuni in the presence of mucins.Cellular microbiology · 2020Article
Corrections and comments
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Authors and funding
16 authors at 6 institutions in 4 countries.
Funding
Abstract
Although the gastrointestinal pathogen Campylobacter jejuni was considered asaccharolytic, >50% of sequenced isolates possess an operon for L-fucose utilization. In C. jejuni NCTC11168, this pathway confers L-fucose chemotaxis and competitive colonization advantages in the piglet diarrhea model, but the catabolic steps remain unknown. Here we solved the putative dehydrogenase structure, resembling FabG of Burkholderia multivorans. The C. jejuni enzyme, FucX, reduces L-fucose and D-arabinose in vitro and both sugars are catabolized by fuc-operon encoded enzymes. This enzyme alone confers chemotaxis to both sugars in a non-carbohydrate-utilizing C. jejuni strain. Although C. jejuni lacks fucosidases, the organism exhibits enhanced growth in vitro when co-cultured with Bacteroides vulgatus, suggesting scavenging may occur. Yet, when excess amino acids are available, C. jejuni prefers them to carbohydrates, indicating a metabolic hierarchy exists. Overall this study increases understanding of nutrient metabolism by this pathogen, and identifies interactions with other gut microbes.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.