Evidence map›Paper›PMID 31924654›Full record

Observational studyJournal of neurology, neurosurgery, and psychiatry2020

Haptoglobin genotype and outcome after spontaneous intracerebral haemorrhage.

Isabel Charlotte Hostettler, Matthew J Morton, Gareth Ambler, Nabila Kazmi, Tom Gaunt, Duncan Wilson, Clare Shakeshaft, H R Jäger, Hannah Cohen, Tarek A Yousry and 9 more

Open access · greenAbstract readObservational Study
PubMed Full text at PMC Publisher
In one paragraph

Observational study in Journal of neurology, neurosurgery, and psychiatry, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
0.4field-weighted citation impact, top 37% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 4 citations in OpenAlex.

  1. The Haptoglobin Response after Aneurysmal Subarachnoid Haemorrhage.International journal of molecular sciences · 2023
    Article
  2. Review
  3. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

19 authors at 9 institutions in 1 country.

Isabel Charlotte HostettlerStroke Research Centre, University College London, Queen Square Institute of Neurology, London, UK.ORCID 0000-0002-9004-2540
Matthew J MortonClinical Neurosciences, Clinical and Experimental Sciences, Faculty of Medicine, University of Southampton, Southampton, UK.
Gareth AmblerDepartment of Statistical Science, University College London, London, UK.
Nabila KazmiMRC Integrative Epidemiology Unit (IEU), Faculty of Health Sciences, University of Bristol, Bristol, UK.
Tom GauntMRC Integrative Epidemiology Unit (IEU), Faculty of Health Sciences, University of Bristol, Bristol, UK.
Duncan WilsonStroke Research Centre, University College London, Queen Square Institute of Neurology, London, UK.
Clare ShakeshaftStroke Research Centre, University College London, Queen Square Institute of Neurology, London, UK.
H R JägerNeuroradiological Academic Unit, Department of Brain Repair and Rehabilitation, University College London, Queen Square Institute of Neurology, London, UK.
Hannah CohenDepartment of Haematology, University College London, London, UK.
Tarek A YousryNeuroradiological Academic Unit, Department of Brain Repair and Rehabilitation, University College London, Queen Square Institute of Neurology, London, UK.
Rustam Al-Shahi SalmanCentre for Clinical Brain Sciences, University of Edinburgh, Edinburgh, UK.
Gregory LipLiverpool Centre for Cardiovascular Science, University of Liverpool and Liverpool Heart and Chest Hospital, Liverepool, UK.
Martin M BrownStroke Research Centre, University College London, Queen Square Institute of Neurology, London, UK.
Keith MuirInstitute of Neuroscience and Psychology, Queen Elizabeth University Hospital, University of Glasgow, Glasgow, UK.
Henry HouldenMRC Centre for Neuromuscular Diseases, Department of Neuromuscular Diseases, UCL Queen Square Institute of Neurology and National Hospital for Neurology and Neurosurgery, London, UK.ORCID 0000-0002-2866-7777
Diederik O BultersDepartment of Neurosurgery, University Hospital Southampton NHS Foundation Trust, Southampton, UK.
Ian GaleaFaculty of Medicine, University of Southampton, Southampton, UK.ORCID 0000-0002-1268-5102
David J WerringStroke Research Centre, University College London, Queen Square Institute of Neurology, London, UK d.werring@ucl.ac.uk.
CROMIS-2 collaborators
National Hospital for Neurology and Neurosurgery · GBUniversity College London · GBUniversity of Bristol · GBUniversity of Southampton · GBQueen Elizabeth University Hospital · GBUK Dementia Research Institute · GBUniversity Hospital Southampton NHS Foundation Trust · GBUniversity of Edinburgh · GBUniversity of Liverpool · GB

Funding

Cancer Research UK A19169Cancer Research UK C18281/A19169Department of HealthMedical Research Council G1002605Medical Research Council MC_PC_15018Medical Research Council MC_PC_19009Medical Research Council MC_UU_00011/4Medical Research Council MR/L01453X/1Medical Research Council MR/M009106/1Wellcome Trust 102215Wellcome Trust 102215/2/13/2
6 · The paper itself

Abstract

objectiveHaptoglobin is a haemoglobin-scavenging protein that binds and neutralises free haemoglobin and modulates inflammation and endothelial progenitor cell function. A

methodsWe included patients with neuroimaging-proven ICH, available DNA and 6-month follow-up in an observational cohort study (CROMIS-2). We classified patients into three groups according to the

resultsWe included 731 patients (mean age 73.4, 43.5% female). Distribution of

conclusionThe HP2-1 genotype might be associated with lower 6-month mortality after ICH; this finding merits further study.

Indexed as

AgedCerebral HemorrhageCohort StudiesDNA Copy Number VariationsFemaleGenotypeHaptoglobinsHumansMaleMiddle AgedPolymorphism, Single NucleotideRecovery of FunctionSurvival RateHaptoglobinscerebrovascular diseasecongnitionMRIstroke

Identifiers

PMID31924654
PMCPMC7612606
OpenAlexW2999488677

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.