ArticleTicks and tick-borne diseases2020
Ixodes scapularis saliva components that elicit responses associated with acquired tick-resistance.
Article in Ticks and tick-borne diseases, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 24 papers.
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Who cites it
24 citing papers in PubMed, 48 citations in OpenAlex.
- Cattle Immunization with T7 Phage-Displayed Whole-Tick Antigens ReducesPathogens (Basel, Switzerland) · 2026Article
- Tick feeding or vaccination with tick antigens elicits immunity to theScience translational medicine · 2025Article
- Research progress toward arthropod salivary protein vaccine development for vector-borne infectious diseases.PLoS neglected tropical diseases · 2024Review
- mRNA vaccination of rabbits alters the fecundity, but not the attachment, of adult Ixodes scapularis.Scientific reports · 2024Article
- Article
- Allergic reactions to tick saliva components in zebrafish model.Parasites & vectors · 2023Article
- Article
- Rodent-targeted approaches to reduce acarological risk of human exposure to pathogen-infected Ixodes ticks.Ticks and tick-borne diseases · 2023Review
- Repeated Tick Infestations ImpairPathogens (Basel, Switzerland) · 2023Article
- Personal protection measures to prevent tick bites in the United States: Knowledge gaps, challenges, and opportunities.Ticks and tick-borne diseases · 2022Review
- Identification of microRNAs in the Lyme Disease VectorInternational journal of molecular sciences · 2022Article
- Host Immune Responses to Salivary Components - A Critical Facet of Tick-Host Interactions.Frontiers in cellular and infection microbiology · 2022Review
- Article
- Probing an Ixodes ricinus salivary gland yeast surface display with tick-exposed human sera to identify novel candidates for an anti-tick vaccine.Scientific reports · 2021Article
- Review
- Tick host immunity: vector immunomodulation and acquired tick resistance.Trends in immunology · 2021Review
- Acquired tick resistance: The trail is hot.Parasite immunology · 2021Review
- The genus Anaplasma: drawing back the curtain on tick-pathogen interactions.Pathogens and disease · 2021Review
- Induced Transient Immune Tolerance in Ticks and Vertebrate Host: A Keystone of Tick-Borne Diseases?Frontiers in immunology · 2021Review
- Recent Progress in Lyme Disease and Remaining Challenges.Frontiers in medicine · 2021Review
Corrections and comments
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Authors and funding
15 authors at 5 institutions in 4 countries.
Funding
Abstract
Ticks and tick-borne diseases are on the rise world-wide and vaccines to prevent transmission of tick-borne diseases is an urgent public health need. Tick transmission of pathogens to the mammalian host occurs during tick feeding. Therefore, it is reasoned that vaccine targeting of tick proteins essential for feeding would thwart tick feeding and consequently prevent pathogen transmission. The phenomenon of acquired tick-immunity, wherein, repeated tick infestations of non-natural hosts results in the development of host immune responses detrimental to tick feeding has served as a robust paradigm in the pursuit of tick salivary antigens that may be vaccine targeted. While several salivary antigens have been identified, immunity elicited against these antigens have only provided modest tick rejection. This has raised the possibility that acquired tick-immunity is directed against tick components other than tick salivary antigens. Using Ixodes scapularis, the blacklegged tick, that vectors several human pathogens, we demonstrate that immunity directed against tick salivary glycoproteins is indeed sufficient to recapitulate the phenomenon of tick-resistance. These observations emphasize the utility of tick salivary glycoproteins as viable vaccine targets to thwart tick feeding and direct our search for anti-tick vaccine candidates.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.