Evidence map›Paper›PMID 31924423›Full record

ArticleUltrasound in medicine & biology2020

Sonoreperfusion therapy for microvascular obstruction: A step toward clinical translation.

Filip Istvanic, Gary Z Yu, Francois T H Yu, Jeff Powers, Xucai Chen, John J Pacella

Registry-linked trialAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Ultrasound in medicine & biology, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT04640038 (Contrast Enhanced Ultrasound), which is not on this map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT04640038 phase3completednot on this map

Contrast Enhanced Ultrasound (CEUS) Detection of Microvascular Perfusion Impairment in COVID-19 Pediatric Patients

TypeinterventionalSponsorChildren's Hospital of PhiladelphiaRan2020 to 2021Enrolled4ConditionsCovid19, Multisystem Inflammatory Syndrome in Children (MIS-C)ArmsSulfur hexafluoride lipid-type A microspheres
3 · Its place in the literature

Who cites it

4 citing papers in PubMed.

  1. Sononeoperfusion: a new therapeutic effect to enhance tumour blood perfusion using diagnostic ultrasound and microbubbles.Cancer imaging : the official publication of the International Cancer Imaging Society · 2023
    Article
  2. Article
  3. Article
  4. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Filip IstvanicCenter for Ultrasound Molecular Imaging and Therapeutics, Department of Medicine, University of Pittsburgh, Pittsburgh, Pennsylvania, USA.
Gary Z YuCenter for Ultrasound Molecular Imaging and Therapeutics, Department of Medicine, University of Pittsburgh, Pittsburgh, Pennsylvania, USA.
Francois T H YuCenter for Ultrasound Molecular Imaging and Therapeutics, Department of Medicine, University of Pittsburgh, Pittsburgh, Pennsylvania, USA; Microbubble Theranostic Laboratory, Department of Radiology, University of Montreal Hospital Research Center, Montreal, Quebec, Canada.
Jeff PowersPhilips Ultrasound, Bothell, Washington, USA.
Xucai ChenCenter for Ultrasound Molecular Imaging and Therapeutics, Department of Medicine, University of Pittsburgh, Pittsburgh, Pennsylvania, USA.
John J PacellaCenter for Ultrasound Molecular Imaging and Therapeutics, Department of Medicine, University of Pittsburgh, Pittsburgh, Pennsylvania, USA. Electronic address: pacellajj@upmc.edu.

Funding

University of Pittsburgh Clinical and Translational Science InstituteUL1TR001857 · NCATS · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI REIS, STEVEN E · 2016 to 2025
$129.3M
TRAINING PROGRAM FOR MD/PHD STUDENTST32GM008208 · NIGMS · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI STEINMAN, RICHARD A · 1987 to 2021
$15.4M
Cardiovascular Bioengineering Training ProgramT32HL076124 · NHLBI · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI SANJEEV G SHROFF · 2005 to 2026
$7.0M
Ultrasound Targeted Microbubble Cavitation to Treat Coronary Microvascular ObstructionR01HL157497 · NHLBI · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI PACELLA, JOHN J · 2021 to 2025
$3.5M
Microbubble-Medicated Ultrasonic Therapy for Microvascular ObstructionR01HL125777 · NHLBI · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI PACELLA, JOHN J · 2015 to 2019
$3.4M
Focal delivery of nitro-oleic acid using ultrasound targeted microbubble cavitation for the treatment of microvascular obstructionR21HL152312 · NHLBI · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI PACELLA, JOHN J · 2021 to 2022
$434k
NCATS NIH HHS UL1 TR001857NHLBI NIH HHS R01 HL125777NHLBI NIH HHS R01 HL157497NHLBI NIH HHS R21 HL152312NHLBI NIH HHS T32 HL076124NIGMS NIH HHS T32 GM008208
6 · The paper itself

Abstract

Sonoreperfusion therapy is being developed as an intervention for the treatment of microvascular obstruction. We investigated the reperfusion efficacy of two clinical ultrasound systems (a modified Philips EPIQ and a Philips Sonos 7500) in a rat hindlimb microvascular obstruction model. Four ultrasound conditions were tested using 20 min treatments: Sonos single frame, Sonos multi-frame, EPIQ low pressure and EPIQ high pressure. Contrast-enhanced perfusion imaging of the microvasculature was conducted at baseline and after treatment to calculate microvascular blood volume (MBV). EPIQ high pressure treatment resulted in significant recovery of MBV from microvascular obstruction, returning to baseline levels after treatment. EPIQ low pressure and Sonos multi-frame treatment resulted in significantly improved MBV after treatment but below baseline levels. Sonos single-frame and control groups showed no improvement post-treatment. This study demonstrates that the most effective sonoreperfusion therapy occurs at high acoustic pressure coupled with high acoustic intensity. Moreover, a clinically available ultrasound system is readily capable of delivering these effective therapeutic pulses.

Indexed as

Ultrasonic TherapyAnimalsHindlimbMaleMicrovesselsPerfusion ImagingRatsRats, WistarThrombosisTranslational Research, BiomedicalCardiac diseaseContrast agentsMicrovascular obstructionUltrasound

Identifiers

PMID31924423
PMCPMC7010545

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Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.