ArticleBiological psychiatry2020
The Thalamocortical Circuit of Auditory Mismatch Negativity.
Article in Biological psychiatry, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 52 papers.
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Who cites it
52 citing papers in PubMed.
- Mismatch negativity as an index of target engagement for excitation/inhibition-based treatment development: a double-blind, placebo-controlled, randomized, single-dose cross-over study of the serotonin type-3 receptor antagonist CVN058.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2022Trial
- Apical integration theory provides a neural basis for understanding disorganization and consciousness in the schizophrenias.Current research in neurobiology · 2026Article
- Mismatch negativity matures in adolescence and without sensitivity to microglial depletion.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2026Article
- Atypical auditory cortical processing in ADHD during early and middle childhood.Developmental cognitive neuroscience · 2026Article
- Distinct Auditory Thalamocortical Pathologies Underlie Emerging Neurophysiological Dysfunction in a Cln3 Mouse Model of Batten Disease.bioRxiv : the preprint server for biology · 2026Article
- Predictive acoustical processing in human cortical layers.Nature communications · 2026Article
- Hierarchical transformations in sound envelope encoding differ across cortical layers.Cerebral cortex (New York, N.Y. : 1991) · 2026Article
- Spectrotemporal signatures of driving and modulatory circuits across cortical and subcortical networks.bioRxiv : the preprint server for biology · 2026Article
- Computational Modelling of Novelty Detection in the Mismatch Negativity Protocols and Its Impairments in Schizophrenia.The European journal of neuroscience · 2026Article
- Spectrotemporal signatures of driving- and modulatory circuits across cortical and subcortical networks.Frontiers in human neuroscience · 2026Article
- Cross-spatial scale processing of hierarchical auditory sequences in human brains revealed using 7 T magnetic resonance imaging.Nature communications · 2025Article
- Neurophysiology of mismatch negativity generation: a biophysical modeling study.bioRxiv : the preprint server for biology · 2025Article
- Sex-specific and age-related progression of auditory neurophysiological deficits in the Cln3 mouse model of Batten disease.Journal of neurodevelopmental disorders · 2025Article
- Mismatch negativity develops in adolescence and independently of microglia.bioRxiv : the preprint server for biology · 2025Article
- Computational modelling of novelty detection in the mismatch negativity protocols and its impairments in schizophrenia.bioRxiv : the preprint server for biology · 2025Article
- Complementary functional profiles of mismatch responses mediated by adaptation and deviance detection point to two distinct auditory short-term memory systems.Journal of neurophysiology · 2025Article
- Predictive coding: a more cognitive process than we thought?Trends in cognitive sciences · 2025Review
- Altered theta band and theta/beta ratio in mismatch negativity associate with treatment effect in schizophrenia with auditory hallucinations.Schizophrenia research. Cognition · 2025Article
- Evidence for Auditory Stimulus-Specific Adaptation But Not Deviance Detection in Larval Zebrafish Brains.The Journal of comparative neurology · 2025Article
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Abstract
backgroundMismatch negativity (MMN) is an extensively validated biomarker of cognitive function across both normative and clinical populations and has previously been localized to supratemporal auditory cortex. MMN is thought to represent a comparison of the features of the present stimulus versus a mnemonic template formed by the prior stimuli.
methodsWe used concurrent thalamic and primary auditory cortical (A1) laminar recordings in 7 macaques to evaluate the relative contributions of core (lemniscal) and matrix (nonlemniscal) thalamic afferents to MMN generation.
resultsWe demonstrated that deviance-related activity is observed mainly in matrix regions of auditory thalamus, MMN generators are most prominent in layer 1 of cortex as opposed to sensory responses that activate layer 4 first and sequentially all cortical layers, and MMN is elicited independent of the frequency tuning of A1 neuronal ensembles. Consistent with prior reports, MMN-related thalamocortical activity was strongly inhibited by ketamine.
conclusionsTaken together, our results demonstrate distinct matrix versus core thalamocortical circuitry underlying the generation of a higher-order brain response (MMN) versus sensory responses.
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