ArticleParasites & vectors2020
Anopheles gambiae populations from Burkina Faso show minimal delayed mortality after exposure to insecticide-treated nets.
Article in Parasites & vectors, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 32 papers.
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Who cites it
32 citing papers in PubMed, 68 citations in OpenAlex.
- Outdoor residual spraying for malaria vector-control in Kayin (Karen) state, Myanmar: A cluster randomized controlled trial.PloS one · 2022Trial
- Impact of insecticide resistance evolution on malaria vector control.PLoS computational biology · 2026Article
- Multi-omics analysis identifies loci associated with pyrethroid resistance across sister species in the Anopheles gambiae species complex.BMC genomics · 2026Article
- The β-triketone, nitisinone, kills insecticide-resistant mosquitoes through cuticular uptake.Parasites & vectors · 2025Article
- Human IgG responses to Anopheles gambiae immunogenic salivary proteins in urban and rural populations of Burkina Faso: biomarkers of exposure to malaria vector bites.Parasites & vectors · 2025Article
- Insecticide resistant Anopheles from Ethiopia but not Burkina Faso show a microbiota composition shift upon insecticide exposure.Parasites & vectors · 2025Article
- Relationship between malaria vector survival, infectivity, and insecticide-treated net use in western Kenya.Parasites & vectors · 2024Article
- Measuring insecticide resistance in a vacuum: exploring next steps to link resistance data with mosquito control efficacy.Journal of medical entomology · 2024Review
- Video-trackedRoyal Society open science · 2024Article
- Relationship between malaria vector survival, infectivity and insecticide treated net use in western Kenya.Research square · 2024Article
- An analytically tractable, age-structured model of the impact of vector control on mosquito-transmitted infections.PLoS computational biology · 2024Article
- Pyrethroid-treated bed nets impair blood feeding performance in insecticide resistant mosquitoes.Scientific reports · 2023Article
- Impact of insecticide resistance on malaria vector competence: a literature review.Malaria journal · 2023Review
- Omitting age-dependent mosquito mortality in malaria models underestimates the effectiveness of insecticide-treated nets.PLoS computational biology · 2022Article
- A closer look at the WHO cone bioassay: video analysis of the hidden effects of a human host on mosquito behaviour and insecticide contact.Malaria journal · 2022Article
- Reduced performance of community bednets against pyrethroid-resistant Anopheles funestus and Anopheles gambiae, major malaria vectors in Cameroon.Parasites & vectors · 2022Article
- Article
- Association of Reduced Long-Lasting Insecticidal Net Efficacy and Pyrethroid Insecticide Resistance With Overexpression of CYP6P4, CYP6P3, and CYP6Z1 in Populations of Anopheles coluzzii From Southeast Côte d'Ivoire.The Journal of infectious diseases · 2022Article
- Use of novel lab assays to examine the effect of pyrethroid-treated bed nets on blood-feeding success and longevity of highly insecticide-resistant Anopheles gambiae s.l. mosquitoes.Parasites & vectors · 2022Article
- The effect of blood feeding on insecticide resistance intensity and adult longevity in the major malaria vector Anopheles funestus (Diptera: Culicidae).Scientific reports · 2022Article
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Authors and funding
5 authors at 3 institutions in 2 countries.
Funding
Abstract
backgroundThe efficacy of long-lasting insecticidal nets (LLINs) in preventing malaria in Africa is threatened by insecticide resistance. Bioassays assessing 24-hour mortality post-LLIN exposure have established that resistance to the concentration of pyrethroids used in LLINs is widespread. However, although mosquitoes may no longer be rapidly killed by LLIN exposure, a delayed mortality effect has been shown to reduce the transmission potential of mosquitoes exposed to nets. This has been postulated to partially explain the continued efficacy of LLINs against pyrethroid-resistant populations. Burkina Faso is one of a number of countries with very high malaria burdens and pyrethroid-resistant vectors, where progress in controlling this disease has stagnated. We measured the impact of LLIN exposure on mosquito longevity in an area of the country with intense pyrethroid resistance to establish whether pyrethroid exposure was still shortening mosquito lifespan in this setting.
methodsWe quantified the immediate and delayed mortality effects of LLIN exposure using standard laboratory WHO cone tests, tube bioassays and experimental hut trials on Anopheles gambiae populations originating from the Cascades region of Burkina Faso using survival analysis and a Bayesian state-space model.
resultsFollowing single and multiple exposures to a PermaNet 2.0 LLIN only one of the four mosquito populations tested showed evidence of delayed mortality. No delayed mortality was seen in experimental hut studies using LLINs. A delayed mortality effect was only observed in WHO tube bioassays when deltamethrin concentration was increased above the standard diagnostic dose.
conclusionsAs mosquito pyrethroid-resistance increases in intensity, delayed effects from LLIN exposure are substantially reduced or absent. Given the rapid increase in resistance occurring in malaria vectors across Africa it is important to determine whether the failure of LLINs to shorten mosquito lifespan is now a widespread phenomenon as this will have important implications for the future of this pivotal malaria control tool.
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