ArticleItalian journal of pediatrics2020
Epidemiology and drug allergy results in children investigated in allergy unit of a tertiary-care paediatric hospital setting.
Article in Italian journal of pediatrics, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.
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Who cites it
12 citing papers in PubMed, 25 citations in OpenAlex.
- Clinical and behavioral determinants in pediatric non-immediate drug hypersensitivity: Low confirmation but persistent avoidance.Pediatric allergy and immunology : official publication of the European Society of Pediatric Allergy and Immunology · 2026Article
- Drug hypersensitivity reactions in children in clinical practice: A WAO Statement.The World Allergy Organization journal · 2025Review
- Outcomes of drug provocation tests in children with chronic complications and comorbidities: Case series.The journal of allergy and clinical immunology. Global · 2025Article
- Evaluation of drug-related anaphylaxis in children: multi-center study.European journal of pediatrics · 2025Article
- Article
- An overview of a preliminary multicenter retrospective study on food and drug allergies in Moroccan pediatric population.The Pan African medical journal · 2024Review
- Diagnosing Single and Multiple Drug Hypersensitivity in Children: A Tertiary Care Center Retrospective Study.Children (Basel, Switzerland) · 2022Article
- When toothache results in asthma diagnosis.International journal of occupational medicine and environmental health · 2022Article
- Drug Allergy in Children: What is the Actual Frequency of Drug Allergies?Sisli Etfal Hastanesi tip bulteni · 2022Article
- Is the clinical manifestation of anaphylaxis in children influenced by the trigger of reaction?Postepy dermatologii i alergologii · 2021Article
- Model Based Evaluation of Hypersensitivity Adverse Drug Reactions to Antimicrobial Agents in Children.Frontiers in pharmacology · 2021Review
- Drug Allergy in children: focus on beta-lactams and NSAIDs.Acta bio-medica : Atenei Parmensis · 2020Article
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Authors and funding
8 authors at 2 institutions in 1 country.
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No grant is acknowledged in the PubMed record.
Abstract
BACKGROUND AND
objectiveDrug Hypersensitivity Reactions (DHRs) are considered adverse effects of medications that resemble allergy symptoms. The reported positive clinical history of pediatric drug reactions is about 10%, however, after allergy investigations, only a small percent is confirmed as hypersensitivity. The aim of this study was to analyze the clinical history, allergy work-up results and sensitization profile of children and adolescents referred to our Allergy Unit for suspected DHRs.
methodsThe study evaluated data related to a group of children with a positive history of drug reactions during a two-year period. The allergy work-up consisted of in vivo and in vitro tests, in accordance with the recommendations of the ENDA/EAACI guidelines.
resultsData from a group of 637 patients [348 M (54.6%); 289 F (45.4%)] were retrospectively analyzed. Beta lactams (BLs) were the most common drugs involved in the reported clinical history, followed by non-steroidal anti-inflammatory drugs (NSAIDs). Severe cutaneous adverse reactions (SCARs) were most frequently observed during BL treatment. The confirmation of BL hypersensitivity was higher for immediate reactions (IRs) [9.4%; 5.1% through positive skin tests (STs) and 5.5% through drug provocation test (DPT)] compared to non-immediate reactions (non-IRs) (8.1%; 2.2% through STs and 6.2% through DPT). A higher number of positive results was obtained for BLs and macrolides when the tests were performed within 12 months after the index reaction (p < 0.05). During DPTs with amoxicillin-clavulanic acid, four hypersensitivity reactions (including one anaphylaxis) occurred despite negative STs.
conclusionOur data demonstrated that only 9.1% of patients resulted in being positive to allergy tests which is in line with the data in literature. An allergy work-up is mandatory for excluding suspected hypersensitivity.
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