SynthesisThe journal of headache and pain2020
The epidemiology of headaches among patients with epilepsy: a systematic review and meta-analysis.
Synthesis in The journal of headache and pain, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers, 1 of them a synthesis that pooled it.
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Who cites it
19 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Prevalence and risk factors of ischemic stroke-related headache in China: a systematic review and meta-analysis.BMC public health · 2022Pooled it
- Clinical characteristics of headache related to epilepsy: experience from a tertiary epilepsy center.BMC neurology · 2025Article
- Global and regional burden, temporal trends, and projections of chronic pain from 1990 to 2032, and its association with cardiovascular diseases: analyses based on global burden of diseases study 2021.Frontiers in public health · 2025Article
- Epilepsy and migraine: a diagnostic and therapeutic challenge.Frontiers in pharmacology · 2025Review
- Analysis of headache burden Chinese in the global context from 1990 to 2021.Frontiers in neurology · 2025Article
- Relationship between migraine and epilepsy in a large population-based cohort: The HUNT Study.European journal of neurology · 2024Article
- A cross-sectional, multicenter survey of the prevalence and influencing factors for migraine in epilepsy.Epilepsia open · 2024Article
- Primary Headache Is Related to Reduced Health-Related Quality of Life in Children with Epilepsy.Healthcare (Basel, Switzerland) · 2024Article
- Migraine - a borderland disease to epilepsy: near it but not of it.The journal of headache and pain · 2024Review
- Global, regional, and national epidemiology of migraine and tension-type headache in youths and young adults aged 15-39 years from 1990 to 2019: findings from the global burden of disease study 2019.The journal of headache and pain · 2023Article
- Article
- Primary headache types in adult epilepsy patients.European journal of medical research · 2023Article
- Antiseizure Medications for the Prophylaxis of Migraine during the Anti- CGRP Drugs Era.Current neuropharmacology · 2023Review
- Applying a biopsychosocial model to migraine: rationale and clinical implications.The journal of headache and pain · 2022Review
- A complex systems view on the current hypotheses of epilepsy pharmacoresistance.Epilepsia open · 2022Review
- Headache in people with epilepsy.Nature reviews. Neurology · 2021Review
- Pathophysiological Bases of Comorbidity in Migraine.Frontiers in human neuroscience · 2021Review
- Epileptic seizures.Discoveries (Craiova, Romania) · 2020Review
- Headache comorbidity in epilepsy and functional/dissociative seizures: an exploratory cross-sectional study in a tertiary epilepsy center.Frontiers in neurologyArticle
Corrections and comments
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Authors and funding
3 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundHeadache is the symptom of pain in the face, head or neck that causes disability in most people with medical and neurological disorders. It frequently co-occurs with most chronic diseases such as epilepsy and significantly impacts the quality of life. However, epidemiologic data from different studies showed different rates of prevalence. Therefore, we conducted this review to summarize the available epidemiologic evidence on the topic and formulate recommendations for future research and clinical practice.
methodsWe followed the preferred reporting items for systematic review and meta-analysis (PRISMA) guidelines. We systematically searched the literature using popular databases such as PubMed, EMBASE, Psych-INFO, and SCOPUS. We further scanned the reference lists of the eligible studies to supplement our electronic search. The Comprehensive Meta-Analysis software version 3.0 (CMA 3.0) was used to conduct a meta-analysis. Subgroup and sensitivity analysis were performed and Cochran's Q- and the I
resultsA total of 17 studies conducted both in developed and developing countries including 5564 study participants were combined in this meta-analysis. The pooled estimated prevalence of headache among patients with epilepsy was 48.4%. The pooled estimated prevalence of Inter-Ictal headache (IIH) (42.2%) and Postictal headache (PIH) (43.1%) were higher when compared to tension-type headache (TTH) (26.2%), migraine with aura (26.0%) and migraine without aura (10.4%). The pooled prevalence of headache was 50.6% and 49.5% for developed and developing countries respectively. The pooled prevalence of headache among patients with epilepsy was considerably higher among females (63.0%) when compared to males (33.3%). Moreover, the pooled estimated prevalence of headache among patients with epilepsy was ranging from 46.0% to 52.2% in a leave-one-out sensitivity analysis.
conclusionThe pooled estimated prevalence of headache among patients with epilepsy was considerably high (48.4%). Screening and appropriate management of headaches among patients with epilepsy are warranted.
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