Evidence map›Paper›PMID 31924102›Full record

ArticleInterventional neuroradiology : journal of peritherapeutic neuroradiology, surgical procedures and related neurosciences2020

The role of diabetes mellitus on the thrombus composition in patients with acute ischemic stroke.

Gengfan Ye, Qun Gao, Peng Qi, Junjie Wang, Shen Hu, Kunpeng Chen, Tianhua Tan, Jun Lu, Daming Wang

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Article in Interventional neuroradiology : journal of peritherapeutic neuroradiology, surgical procedures and related neurosciences, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
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20citing papers in PubMed, 2 pooled it
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1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

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3 · Its place in the literature

Who cites it

20 citing papers in PubMed, 2 syntheses or guidelines pooled it.

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4 · The record

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5 · Who and what money

Authors and funding

9 authors.

Gengfan YeDepartment of Neurosurgery, Beijing Hospital, National Center of Gerontology, Beijing, China.ORCID https://orcid.org/0000-0002-7298-2571
Qun GaoDepartment of Neurosurgery, Beijing Hospital, National Center of Gerontology, Beijing, China.
Peng QiDepartment of Neurosurgery, Beijing Hospital, National Center of Gerontology, Beijing, China.
Junjie WangDepartment of Neurosurgery, Beijing Hospital, National Center of Gerontology, Beijing, China.
Shen HuDepartment of Neurosurgery, Beijing Hospital, National Center of Gerontology, Beijing, China.
Kunpeng ChenDepartment of Neurosurgery, Beijing Hospital, National Center of Gerontology, Beijing, China.
Tianhua TanDepartment of Neurosurgery, Beijing Hospital, National Center of Gerontology, Beijing, China.
Jun LuDepartment of Neurosurgery, Beijing Hospital, National Center of Gerontology, Beijing, China.
Daming WangDepartment of Neurosurgery, Beijing Hospital, National Center of Gerontology, Beijing, China.ORCID https://orcid.org/0000-0001-7333-4835

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

purposeDiabetes mellitus indicated poor clinical prognosis for patients with acute ischemic stroke. Furthermore, diabetes mellitus could also impact the hemostatic system, while its influence on the histological composition of thrombus is unclear.

methodsConsecutive patients with retrieved clots were included. Histologic staining for thrombus included hematoxylin and eosin, Martius Scarlet Blue, immunohistochemistry for von Willebrand factor. The differences in clot composition were compared according to diabetes mellitus history or hyperglycemia (≥7.8 mmol/L) on admission.

resultsA total of 52 patients were included; half of them were diagnosed as diabetes mellitus previously. Diabetic patients showed higher serum glucose on admission (8.90 vs. 7.40, p = 0.012). The baseline characteristics (expect smoking history and thrombus location), procedural, and clinical outcomes were similar between diabetic patients and nondiabetic patients. As for histologic composition, thrombus in patients with diagnosed diabetes mellitus had more fibrin (44.2% vs. 28.3%, p = 0.004) and fewer red blood cells (26.0% vs. 42.9%, p = 0.013) and equivalent content of platelets (24.0% vs. 21.5%, p = 0.694) and von Willebrand factor (0.041 vs. 0.031, p = 0.234) than patients without diabetes mellitus. However, there was no statistical difference in the content of red blood cells (41.6% vs. 27.3%, p = 0.105), fibrin (37.6% vs. 34.3%, p = 0.627), platelets (21.2% vs. 24.2%, p = 0.498), and von Willebrand factor (0.038 vs. 0.034, p = 0.284) between patients with or without hyperglycemia on admission.

conclusionClots in diabetic patients had more fibrin and fewer erythrocyte components compared with patients without diabetes mellitus, while hyperglycemia on admission did not show association with clot composition. Further studies are needed to confirm these results.

Indexed as

AgedDiabetes MellitusFemaleHumansIntracranial ThrombosisIschemic StrokeMalePrognosisRisk FactorsThrombectomyAcute ischemic strokediabetes mellitushistologythrombectomythrombus

Identifiers

PMID31924102
PMCPMC7254620

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.