ArticlePediatric research2020
Bidirectional association between GERD and asthma in children: two longitudinal follow-up studies using a national sample cohort.
Article in Pediatric research, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers, 1 of them a synthesis that pooled it.
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Who cites it
9 citing papers in PubMed, 1 synthesis or guideline pooled it, 24 citations in OpenAlex.
- Mendelian Randomization Analysis Reveals a Complex Genetic Interplay among Atopic Dermatitis, Asthma, and Gastroesophageal Reflux Disease.American journal of respiratory and critical care medicine · 2023Pooled it
- Review
- Otolaryngologists Demonstrate Low Agreement on Pediatric Airway Inflammation Assessment.The Laryngoscope · 2025Article
- Shared genetic architecture between gastro-esophageal reflux disease, asthma, and allergic diseases.Communications biology · 2024Article
- Association Between Childhood Asthma and Gastroesophageal Reflux Disease in Children: A Systematic Review.Cureus · 2024Review
- Pediatric asthma comorbidities: Global impact and unmet needs.The World Allergy Organization journal · 2024Review
- Article
- Do not forget asthma comorbidities in pediatric severe asthma!Frontiers in pediatrics · 2022Review
- Energy-drink consumption is associated with asthma, allergic rhinitis, and atopic dermatitis in Korean adolescents.European journal of clinical nutrition · 2021Article
Corrections and comments
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Authors and funding
6 authors at 5 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundThe causal relationship between asthma and gastroesophageal reflux disease (GERD) is unknown in children.
methodsThe Korean Health Insurance Review and Assessment Service-National Sample Cohort 2002-2013 was used. The population age <15 years was selected. In study I, 86,096 asthmatic children were 1:1 matched with 86,096 control I participants. In study II, 532 GERD children were 1:2 matched with 1064 control II participants. The stratified Cox proportional hazard ratios for GERD in patients with asthma (study I) and asthma in patients with GERD (study II) were analyzed.
resultsIn total, 0.7% (583/86,096) of the asthma group and 0.5% (430/86,096) of the control I group had GERD (P < 0.001). The asthma group demonstrated a 1.36 times higher HR for GERD than the control I group (95% CI = 1.20-1.54, P < 0.001). Subgroup analyses according to age and sex showed consistent results. In total, 15.0% (80/532) of the GERD group and 10.0% (106/1,064) of the control II group had asthma (P < 0.001). The GERD group showed a 1.62-fold higher HR for asthma than the control II group (95% CI = 1.21-2.18, P < 0.001).
conclusionGERD and asthma demonstrated a bidirectional relationship in children.
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