ArticleEnvironmental research2020
In utero exposure to endocrine-disrupting chemicals and telomere length at birth.
Article in Environmental research, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.
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Who cites it
8 citing papers in PubMed, 22 citations in OpenAlex.
- Exposure to Endocrine Disruptors and Stress Hormones Across Pregnancy Trimesters: Links with Maternal Telomere Length.Journal of xenobiotics · 2026Article
- Gestational phthalate levels and biomarkers of aging in infants and children from New York City.Environmental research · 2025Article
- Maternal Lifestyle During Pregnancy and Its Influence on Offspring's Telomere Length.Life (Basel, Switzerland) · 2025Review
- Associations between prenatal phthalate exposure and childhood epigenetic age acceleration.Environmental research · 2023Article
- Early Environment and Telomeres: a Long-Term Toxic Relationship.Current environmental health reports · 2023Review
- Triclosan is associated with breast cancer via oxidative stress and relative telomere length.Frontiers in public health · 2023Article
- Mixture effects of prenatal exposure to per- and polyfluoroalkyl substances and polybrominated diphenyl ethers on maternal and newborn telomere length.Environmental health : a global access science source · 2021Article
- Determination of prenatal exposure to parabens and triclosan and estimation of maternal and fetal burden.Toxicology reports · 2021Article
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Authors and funding
4 authors at 3 institutions in 2 countries.
Funding
Abstract
Telomere length correlates with morbidity and mortality. While telomere length appears to be influenced by hormone levels, the potential impact of exposure to endocrine-disrupting chemicals (EDCs) has not been studied. We examined the association between maternal gestational concentrations of biomarkers of EDC exposure and telomere length at birth in the Harvard Epigenetic Birth Cohort. EDC (phenols and phthalates) biomarker concentrations were measured in maternal spot urine samples during the first trimester and telomere length in maternal and cord blood collected at delivery among 181 mother-newborn singleton dyads. Maternal and newborn telomere length exhibited a positive correlation (Spearman ρ = 0.20 (p-value< 0.01). Infant telomere length was associated with maternal biomarker concentrations of specific EDCs, and most of these associations were observed to be infant sex-specific. Prenatal exposure to triclosan, a non-paraben phenol with antimicrobial properties, was one of the most strongly associated EDCs with telomere length; telomere length was 20% (95% CI 5%-33%) shorter among boys in the highest quartile of maternal biomarker concentrations compared to the lowest quartile. In contrast, we observed longer telomere length associated with increased gestational concentrations of mono-isobutyl phthalate, and among boys, with increased concentrations of mono-2-ethylhexyl phthalate. In this birth cohort, we observed associations between maternal gestational exposure to select EDC biomarkers and telomere length, most of which were sex-specific. These findings need to be confirmed in future studies.
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Registered trials
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