Evidence map›Paper›PMID 31923844›Full record

ArticleNeoplasia (New York, N.Y.)2020

Irreversible and sustained upregulation of endothelin axis during oncogene-associated pancreatic inflammation and cancer.

Suprit Gupta, Avi Prajapati, Mansi Gulati, Shailendra K Gautam, Sushil Kumar, Vipin Dalal, Geoffrey A Talmon, Satyanarayana Rachagani, Maneesh Jain

Abstract read
In one paragraph

Article in Neoplasia (New York, N.Y.), 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.

0numbers the graph read from it
0cells of the map it votes in
15citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

15 citing papers in PubMed.

  1. Article
  2. Article
  3. Article
  4. Article
  5. Article
  6. Endothelin-3 is epigenetically silenced in endometrioid endometrial cancer.Journal of cancer research and clinical oncology · 2023
    Article
  7. Article
  8. Review
  9. Review
  10. Modeling pancreatic cancer in mice for experimental therapeutics.Biochimica et biophysica acta. Reviews on cancer · 2021
    Review
  11. YAP and endothelin-1 signaling: an emerging alliance in cancer.Journal of experimental & clinical cancer research : CR · 2021
    Review
  12. Article
  13. Article
  14. Review
  15. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Suprit GuptaDepartment of Biochemistry and Molecular Biology, University of Nebraska Medical Center, Omaha, NE 68198, USA.
Avi PrajapatiDepartment of Biochemistry and Molecular Biology, University of Nebraska Medical Center, Omaha, NE 68198, USA.
Mansi GulatiDepartment of Biochemistry and Molecular Biology, University of Nebraska Medical Center, Omaha, NE 68198, USA.
Shailendra K GautamDepartment of Biochemistry and Molecular Biology, University of Nebraska Medical Center, Omaha, NE 68198, USA.
Sushil KumarDepartment of Biochemistry and Molecular Biology, University of Nebraska Medical Center, Omaha, NE 68198, USA.
Vipin DalalDepartment of Biochemistry and Molecular Biology, University of Nebraska Medical Center, Omaha, NE 68198, USA.
Geoffrey A TalmonPathology and Microbiology, University of Nebraska Medical Center, Omaha, NE 68198, USA.
Satyanarayana RachaganiDepartment of Biochemistry and Molecular Biology, University of Nebraska Medical Center, Omaha, NE 68198, USA.
Maneesh JainDepartment of Biochemistry and Molecular Biology, University of Nebraska Medical Center, Omaha, NE 68198, USA; Fred and Pamela Buffett Cancer Center, University of Nebraska Medical Center, Omaha, NE 68198, USA. Electronic address: mjain@unmc.edu.

Funding

Validation of biomarkers for risk prediction and early diagnosis of Pancreatic AdenocarcinomaU01CA200466 · NCI · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI Surinder K. Batra, Randall Brand · 2016 to 2026
$11.3M
Nanovaccine platforms to combat pancreatic cancerU01CA213862 · NCI · IOWA STATE UNIVERSITY · PI JAIN, MANEESH, NARASIMHAN, BALAJI · 2017 to 2021
$2.7M
Targeted Radiation Therapy for Pancreatic CancerR01CA195586 · NCI · UNIVERSITY OF NEBRASKA MEDICAL CENTER · PI BATRA, SURINDER K., JAIN, MANEESH · 2015 to 2019
$2.2M
NCI NIH HHS R01 CA195586NCI NIH HHS U01 CA200466NCI NIH HHS U01 CA213862
6 · The paper itself

Abstract

Endothelin-1 (ET-1) and its two receptors, endothelin receptor A (ET

Indexed as

AmylasesAnimalsCeruletideDisease Models, AnimalEndothelin-1Endothelin-Converting EnzymesGene Expression RegulationHumansInflammationMiceOncogenesPancreatic NeoplasmsPancreatitisProto-Oncogene Proteins p21(ras)Receptor, Endothelin AReceptor, Endothelin BAmylasesCeruletideECE1 protein, humanEDNRA protein, humanEDNRB protein, humanEndothelin-1Endothelin-Converting EnzymesHras protein, mouseProto-Oncogene Proteins p21(ras)Receptor, Endothelin AReceptor, Endothelin BAcinar-ductal metaplasiaEndothelinOncogenic K-rasPancreatic injuryPancreatitisPanIN lesionsPrecancerous lesions

Identifiers

PMID31923844
PMCPMC6951489

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.