ReviewAnnals of allergy, asthma & immunology : official publication of the American College of Allergy, Asthma, & Immunology2020
Reaction phenotypes in IgE-mediated food allergy and anaphylaxis.
Review in Annals of allergy, asthma & immunology : official publication of the American College of Allergy, Asthma, & Immunology, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 25 papers.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
25 citing papers in PubMed, 49 citations in OpenAlex.
- Prevalence and Risk Factors of Food Allergy and Its Association With Asthma Coexistence and Severity in Bangladeshi Schoolchildren: A GIS-Based Cross-Sectional Study.Food science & nutrition · 2026Article
- Review
- Allergenicity assessment of novel foods - lessons from immune endotyping of food-allergic patients.Frontiers in immunology · 2026Review
- Food allergy thresholds, context, and balance in 2025.Journal of food allergy · 2024Article
- Dietary Intervention during Weaning and Development of Food Allergy: What Is the State of the Art?International journal of molecular sciences · 2024Review
- A murine model of peanut-allergic asthma.Frontiers in allergy · 2024Article
- The future of food allergy diagnosis.Frontiers in allergy · 2024Review
- Will Oral Food Challenges Still Be Part of Allergy Care in 10 Years' Time?The journal of allergy and clinical immunology. In practice · 2023Review
- Mast cell-mediated immune regulation in health and disease.Frontiers in medicine · 2023Review
- Real-life evaluation of molecular multiplex IgE test methods in the diagnosis of pollen associated food allergy.Allergy · 2022Article
- Serological profiling reveals hsa-miR-451a as a possible biomarker of anaphylaxis.JCI insight · 2022Article
- Anaphylaxis knowledge gaps and future research priorities: A consensus report.The Journal of allergy and clinical immunology · 2022Article
- Structure, Immunogenicity, and IgE Cross-Reactivity among Walnut and Peanut Vicilin-Buried Peptides.Journal of agricultural and food chemistry · 2022Article
- The 2020 update on anaphylaxis in paediatric population.Postepy dermatologii i alergologii · 2022Review
- Food Allergy a Constant Concern to the Medical World and Healthcare Providers: Practical Aspects.Life (Basel, Switzerland) · 2021Review
- Is the clinical manifestation of anaphylaxis in children influenced by the trigger of reaction?Postepy dermatologii i alergologii · 2021Article
- Mechanisms Governing Anaphylaxis: Inflammatory Cells, Mediators, Endothelial Gap Junctions and Beyond.International journal of molecular sciences · 2021Review
- Differences in gut microbiota between allergic rhinitis, atopic dermatitis, and skin urticaria: A pilot study.Medicine · 2021Observational
- Seasonality of food-related anaphylaxis admissions and associations with temperature and pollen levels.The journal of allergy and clinical immunology. In practice · 2021Article
- CpG Adjuvant in Allergen-Specific Immunotherapy: Finding the Sweet Spot for the Induction of Immune Tolerance.Frontiers in immunology · 2021Review
Corrections and comments
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Authors and funding
5 authors at 1 institution in 3 countries.
Funding
Abstract
objectiveFood allergy encompasses a range of food hypersensitivities. Different clinical phenotypes for food allergy likely exist in much the same way as endotype discovery is now a major research theme in asthma. We discuss the emerging evidence for different reaction phenotypes (ie, symptoms experienced after allergen exposure in food allergic individuals) and their relevance for clinical practice. DATA SOURCES: Published and unpublished literature relating to reaction phenotypes in food allergy. STUDY SELECTIONS: Authors assessment of the available data.
resultsFood anaphylaxis may be pathophysiologically different than anaphylaxis caused by nonfood triggers. Currently, there are no robust, clinically useful predictors of severity in food allergy. It is likely that patient-specific reaction phenotypes exist in food allergy, which may affect the risk of severe anaphylaxis. Allergen immunotherapy may modulate these phenotypes.
conclusionData are emerging to confirm our clinical experience that many food allergic patients experience stereotypical symptoms after allergen exposure, both in the community and at supervised oral food challenge, in a manner that varies among patients. Integrating data sets from different cohorts and applying unbiased machine-based learning analyses may demonstrate specific food allergy endotypes in a similar way to asthma. Whether this results in improvements in patient management (eg, through facilitating risk stratification or affecting the decision to prescribe an epinephrine autoinjector and, perhaps, the number of devices) remains to be determined, but given our current inability to predict which patients are most at risk of severe food allergic reactions, this will clearly be an important area of research in the future.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.