Trial reportJournal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research2020
Effects of Supplemental Vitamin D on Bone Health Outcomes in Women and Men in the VITamin D and OmegA-3 TriaL (VITAL).
Erratum issued 3 registry-linked trialsOpen access · hybridAbstract readRandomized Controlled Trial
In one paragraph
Trial report in Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. It is linked to 3 registered trials, which are not on this map. Cited by 65 papers, 2 of them syntheses that pooled it.
0numbers the graph read from it
0cells of the map it votes in
65citing papers in PubMed, 2 pooled it
10.6field-weighted citation impact, top 1% of its field
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
VITamin D and OmegA-3 TriaL (VITAL): Fractures, Vitamin D and Genetic Markers
VITamin D and OmegA-3 TriaL: Effects on Bone Structure and Architecture
VITamin D and OmegA-3 TriaL: Interrelationship of Vitamin D and Vitamin K on Bone
Who cites it
65 citing papers in PubMed, 2 syntheses or guidelines pooled it, 111 citations in OpenAlex.
- Clinical Practice Guidelines of the Latin American Federation of Endocrinology for the use of vitamin D in the maintenance of bone health: recommendations for the Latin American context.Archives of osteoporosis · 2024Guideline
- The Effects ofNutrients · 2023Pooled it
- Effects of vitamin D3, omega-3s, and a simple home exercise program on incident vertebral fractures: the DO-HEALTH randomized controlled trial.Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research · 2025Trial
- Changes in bone density and microarchitecture following treatment of Graves' disease and the effects of vitamin D supplementation. A randomized clinical trial.Osteoporosis international : a journal established as result of cooperation between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA · 2024Trial
- Supplemental Vitamin D and Incident Fractures in Midlife and Older Adults.The New England journal of medicine · 2022Trial
- Effect of Vitamin D Supplementation on Outcomes in People With Early Psychosis: The DFEND Randomized Clinical Trial.JAMA network open · 2021Trial
- Effects of Vitamin D3 Supplementation on Body Composition in the VITamin D and OmegA-3 TriaL (VITAL).The Journal of clinical endocrinology and metabolism · 2021Trial
- Total, Bioavailable, and Free 25(OH)D Relationship with Indices of Bone Health in Elderly: A Randomized Controlled Trial.The Journal of clinical endocrinology and metabolism · 2021Trial
- VITamin D and OmegA-3 TriaL (VITAL): Effects of Vitamin D Supplements on Risk of Falls in the US Population.The Journal of clinical endocrinology and metabolism · 2020Trial
- Approach to personalizing the treatment of osteoporosis.The Journal of clinical endocrinology and metabolism · 2026Review
- Investigating the interrelationship of vitamin K and vitamin D status on bone density: results from the VITamin D and OmegA-3 TriaL.JBMR plus · 2026Article
- Management of postmenopausal osteoporosis.Endocrine reviews · 2026Review
- Effect of Vitamin D Supplementation Regimens on Fracture Healing and Serum Biomarker Profile in Long-Bone Fractures: A Prospective Randomized Study.Journal of orthopaedic case reports · 2026Article
- The Impact of Serum 25-Hydroxyvitamin D on Bone Mineral Density at Different Skeletal Sites: A Multivariate Analysis Based on a UK Cohort Study.Food science & nutrition · 2026Article
- Effects of dietary vitamin D supplementation on bone microarchitecture, mineralization, and mechanical properties in Wistar rat animal model.Scientific reports · 2026Article
- Sarcopenic obesity and skeletal development in children: recent advances.Frontiers in pediatrics · 2026Review
- Low-Dose Vitamin D3 Supplementation: Associations with Vertebral Fragility and Pedicle Screw Loosening.Journal of clinical medicine · 2025Article
- [Diagnostics and treatment of osteoporosis in 2025 : An update on current guidelines].Innere Medizin (Heidelberg, Germany) · 2025Review
- A comprehensive review and advanced biomolecule-based therapies for osteoporosis.Journal of advanced research · 2025Review
- The role of nutritional vitamin D in chronic kidney disease-mineral and bone disorder in children and adults with chronic kidney disease, on dialysis, and after kidney transplantation-a European consensus statement.Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association · 2025Article
5 more citing papers are in PubMed but not listed here.
Corrections and comments
- Erratum issued
Authors and funding
11 authors at 1 institution in 1 country.
Meryl S LeBoffDivision of Endocrinology, Diabetes, and Hypertension, Department of Medicine, Brigham and Women's Hospital Boston, Boston, MA, USA.ORCID 0000-0001-5797-4947
Sharon H ChouDivision of Endocrinology, Diabetes, and Hypertension, Department of Medicine, Brigham and Women's Hospital Boston, Boston, MA, USA.
Elle M MurataDivision of Endocrinology, Diabetes, and Hypertension, Department of Medicine, Brigham and Women's Hospital Boston, Boston, MA, USA.
Catherine M DonlonDivision of Endocrinology, Diabetes, and Hypertension, Department of Medicine, Brigham and Women's Hospital Boston, Boston, MA, USA.
Nancy R CookHarvard Medical School, Boston, MA, USA.
Samia MoraHarvard Medical School, Boston, MA, USA.
I-Min LeeDivision of Preventive Medicine, Department of Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, USA.
Gregory KotlerDivision of Preventive Medicine, Department of Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, USA.
Vadim BubesDivision of Preventive Medicine, Department of Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, USA.
Julie E BuringHarvard Medical School, Boston, MA, USA.
JoAnn E MansonHarvard Medical School, Boston, MA, USA.
Brigham and Women's Hospital · US
Funding
Harvard Clinical and Translational Science CenterUL1TR001102 · NCATS · HARVARD MEDICAL SCHOOL · PI NADLER, LEE MARSHALL · 2013 to 2017
$106.2MVITamin D and omegA-3 triaL (VITAL)U01CA138962 · NCI · BRIGHAM AND WOMEN'S HOSPITAL · PI BURING, JULIE E., MANSON, JOANN ELISABETH · 2009 to 2014
$23.6MThe VITamin D and OmegA-3 TriaL (VITAL)R01CA138962 · NCI · BRIGHAM AND WOMEN'S HOSPITAL · PI BURING, JULIE E., MANSON, JOANN ELISABETH · 2015 to 2019
$20.9MVITamin D and OmegA-3 TriaL (VITAL): Interrelationship of Vitamin D and Vitamin K on BoneR01AR059775 · NIAMS · BRIGHAM AND WOMEN'S HOSPITAL · PI LEBOFF, MERYL SUSAN · 2012 to 2022
$3.9MReducing Inflammation for the Prevention of CVD: A Focus on Eicosanoid PathwaysR01HL134811 · NHLBI · BRIGHAM AND WOMEN'S HOSPITAL · PI MORA, SAMIA · 2017 to 2020
$3.0MCirculating plasma metabolites, diet, and risk of type 2 diabetesR01DK112940 · NIDDK · BRIGHAM AND WOMEN'S HOSPITAL · PI HU, FRANK B, MORA, SAMIA · 2018 to 2021
$2.9MVITamin D OmegA-3 TriaL (VITAL): Fractures, Vitamin D and Genetic MarkersR01AR070854 · NIAMS · BRIGHAM AND WOMEN'S HOSPITAL · PI LEBOFF, MERYL SUSAN · 2018 to 2022
$2.8MPatient Centered Approaches to Preventing ASCVD EventsK24HL136852 · NHLBI · BRIGHAM AND WOMEN'S HOSPITAL · PI SAMIA MORA · 2018 to 2026
$1.1MVitamin D and Omega-3 Fatty Acids(VITAL Trial): Effects on FracturesR01AR060574 · NIAMS · BRIGHAM AND WOMEN'S HOSPITAL · PI LEBOFF, MERYL SUSAN · 2010 to 2013
$779kCDC HHSNCATS NIH HHS UL1 TR001102NCCIH NIH HHSNCI NIH HHS R01 CA138962NCI NIH HHS U01 CA138962NCRR NIH HHS UL1TR001102NHLBI NIH HHS K24 HL136852NHLBI NIH HHS R01 HL134811NIAMS NIH HHS R01 AR059775NIAMS NIH HHS R01 AR060574NIAMS NIH HHS R01 AR070854NIDDK NIH HHS R01 DK112940NINDS NIH HHS
Abstract
Although supplemental vitamin D is used to promote bone health in the general population, data from randomized controlled trials (RCTs) have been inconsistent. We determined whether daily, vitamin D
Indexed as
Fatty Acids, Omega-3Vitamin DAbsorptiometry, PhotonAdultBone DensityDietary SupplementsFemaleFemur NeckFibroblast Growth Factor-23HumansMaleNetherlandsOutcome Assessment, Health CareFatty Acids, Omega-3FGF23 protein, humanFibroblast Growth Factor-23Vitamin DBONE QCTDXAGENERAL POPULATION STUDIESOSTEOPOROSISPTH/VITD/FGF23
Identifiers
What OpenQuestion holds
Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.