SynthesisPloS one2020
Association between tuberculosis and depression on negative outcomes of tuberculosis treatment: A systematic review and meta-analysis.
Synthesis in PloS one, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 75 papers, 9 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
75 citing papers in PubMed, 9 syntheses or guidelines pooled it, 121 citations in OpenAlex.
- Pooled it
- Depression and health outcomes: An umbrella review of systematic reviews and meta-analyses of observational studies.Translational psychiatry · 2025Pooled it
- Association of smoking with depression among tuberculosis patients: a systematic review and meta-analysis.BMC public health · 2025Pooled it
- Effectiveness of Nursing Care Intervention for Patients With Pulmonary Tuberculosis: A Systematic Review and Meta-Analysis.Nursing open · 2025Pooled it
- Prevalence and risks of tuberculosis multimorbidity in low-income and middle-income countries: a meta-review.BMJ open · 2022Pooled it
- The relationship between mental health and risk of active tuberculosis: a systematic review.BMJ open · 2022Pooled it
- Compliance of Healthcare Worker's toward Tuberculosis Preventive Measures in Workplace: A Systematic Literature Review.International journal of environmental research and public health · 2021Pooled it
- Impact of mental disorders on active TB treatment outcomes: a systematic review and meta-analysis.The international journal of tuberculosis and lung disease : the official journal of the International Union against Tuberculosis and Lung Disease · 2020Pooled it
- Pharmacological or non-pharmacological interventions for treatment of common mental disorders associated with Tuberculosis: A systematic review.Chronic respiratory diseasePooled it
- Cognitive-behavioral therapy on psychological stress and quality of life in subjects with pulmonary tuberculosis: a community-based cluster randomized controlled trial.BMC public health · 2022Trial
- Article
- Impact of COVID-19 on tuberculosis mortality in Japan: a retrospective analysis of national surveillance data from 2017 to 2022.BMC public health · 2026Article
- Comorbidity profiles and their impact on treatment outcomes in elderly patients with pulmonary tuberculosis: a single-center retrospective cohort study.BMC infectious diseases · 2026Article
- Knowledge, Psychological Distress, and Medication Beliefs Among Tuberculosis Patients in Southwest China: A Mediation Analysis.Healthcare (Basel, Switzerland) · 2026Article
- Silent barriers: psycho-social factors and the hidden risk of medication non-adherence among tuberculosis patients in Mongolia.Journal of clinical tuberculosis and other mycobacterial diseases · 2026Article
- Depressive Symptoms in Pediatric Tuberculosis: A Retrospective Two-Time-Point Observational Study.Diseases (Basel, Switzerland) · 2026Article
- Methodologies for studying depression in persons with tuberculosis: A scoping review.PLOS global public health · 2026Article
- Prevalence and associated factors of depression among persons with Tuberculosis in Ghana: A cross-sectional study.SAGE open medicine · 2026Article
- Designing integrated care models for mental health and tuberculosis in Pune, India: A formative qualitative study of patient, caregiver and provider perspectives.Global mental health (Cambridge, England) · 2026Article
- Tuberculosis comorbidities, multimorbidity and mortality amongst adults in South Africa: A prospective cohort study nested in a trial.PLOS global public health · 2026Article
15 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors at 1 institution in 2 countries.
Funding
Abstract
backgroundDepression is a common comorbidity of tuberculosis (TB) and is associated with poor adherence to treatment of multiple disorders. We conducted a systematic review to synthesize the existing evidence on the relationship between depression and negative outcomes of TB treatment.
methodsWe systematically reviewed studies that evaluated depressive symptoms (DS) directly or indirectly through psychological distress (PD) and measured negative treatment outcomes of drug-sensitive pulmonary TB, defined as death, loss to follow-up, or non-adherence. Sources included PubMed, Global Health Library, Embase, Scopus and Web of Science from inception to August 2019.
resultsOf the 2,970 studies initially identified, eight articles were eligible for inclusion and two were used for the primary outcome meta-analysis. We found a strong association between DS and negative TB treatment outcomes (OR = 4.26; CI95%:2.33-7.79; I2 = 0%). DS were also associated with loss to follow-up (OR = 8.70; CI95%:6.50-11.64; I2 = 0%) and death (OR = 2.85; CI95%:1.52-5.36; I2 = 0%). Non-adherence was not associated with DS and PD (OR = 1.34; CI95%:0.70-2.72; I2 = 94.36) or PD alone (OR = 0.92; CI95%:0.81-1.05; I2 = 0%).
conclusionsDS are associated with the negative TB treatment outcomes of death and loss to follow-up. Considerable heterogeneity exists in the definition of depression and outcomes such as non-adherence across the limited number of studies on this topic.
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Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.