Trial reportAnnals of the American Thoracic Society2020
The Effect of Continuous Positive Airway Pressure on Vascular Function and Cardiac Structure in Diabetes and Sleep Apnea. A Randomized Controlled Trial.
Open access · greenAbstract readClinical Trial, Phase IIRandomized Controlled Trial
In one paragraph
Trial report in Annals of the American Thoracic Society, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers, 2 of them syntheses that pooled it.
0numbers the graph read from it
0cells of the map it votes in
15citing papers in PubMed, 2 pooled it
1.8field-weighted citation impact, top 15% of its field
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
15 citing papers in PubMed, 2 syntheses or guidelines pooled it, 25 citations in OpenAlex.
- Association between obstructive sleep apnea syndrome and type1/type2 diabetes mellitus: A systematic review and meta-analysis.Journal of diabetes investigation · 2025Pooled it
- Effects of continuous positive airway pressure therapy on glucose metabolism in patients with obstructive sleep apnoea and type 2 diabetes: a systematic review and meta-analysis.European respiratory review : an official journal of the European Respiratory Society · 2023Pooled it
- Effect of continuous positive airway pressure on ventricular remodeling of patients with combined diabetes mellitus and obstructive sleep apnea: a cross-sectional study and follow-on randomized clinical trial.International journal of cardiology · 2025Trial
- Effect Heterogeneity of CPAP on MACE by Nocturnal Hypoxia Burden in Older Adults OSAS: A Propensity Score Matching Study.Clinical interventions in aging · 2026Article
- A pilot study of high-intensity interval training and continuous positive airway pressure on vascular health in Thai adults with obesity, obstructive sleep apnea, and type 2 diabetes.Preventive medicine reports · 2025Article
- Effects of obstructive sleep apnea on vascular structure and function in adults with obesity and type 2 diabetes: a comparative study.Cardiovascular endocrinology & metabolism · 2025Article
- A Structured Narrative Review of the OSA-T2DM Axis.Journal of clinical medicine · 2025Review
- Effects of Age and Sex on Systemic Inflammation and Cardiometabolic Function in Individuals With Type 2 Diabetes.Journal of the American Heart Association · 2025Article
- The lived experience of positive airway pressure therapy in patients with obstructive sleep apnea across the lifespan: a qualitative study.Journal of clinical sleep medicine : JCSM : official publication of the American Academy of Sleep Medicine · 2024Article
- The causality between obstructive sleep apnea and ventricular structure and function: a bidirectional Mendelian randomization study.Frontiers in genetics · 2023Article
- Cardiovascular Disorders Triggered by Obstructive Sleep Apnea-A Focus on Endothelium and Blood Components.International journal of molecular sciences · 2021Review
- Effect of Obstructive Sleep Apnea and Positive Airway Pressure Therapy on Cardiac Remodeling as Assessed by Cardiac Biomarker and Magnetic Resonance Imaging in Nonobese and Obese Adults.Hypertension (Dallas, Tex. : 1979) · 2021Article
- Endothelial Function and Arterial Stiffness Should Be Measured to Comprehensively Assess Obstructive Sleep Apnea in Clinical Practice.Frontiers in cardiovascular medicine · 2021Article
- Contemporary Concise Review 2019: Sleep and ventilation.Respirology (Carlton, Vic.) · 2020Review
- Cardiovascular risk associated with co-morbid insomnia and sleep apnoea (COMISA) in type 2 diabetics.Sleep science (Sao Paulo, Brazil)Article
Corrections and comments
- Commented on by
Authors and funding
11 authors at 9 institutions in 5 countries.
Jessie P BakkerDivision of Sleep & Circadian Disorders, Brigham and Women's Hospital, Boston, Massachusetts.
Dimitrios BaltzisThe Rongxiang Xu MD Center for Regenerative Therapeutics.
Francesco TecilazichThe Rongxiang Xu MD Center for Regenerative Therapeutics.
Raymond H ChanDepartment of Medicine, Harvard Medical School, Boston, Massachusetts.
Warren J ManningDepartment of Medicine, Harvard Medical School, Boston, Massachusetts.
Tomas G NeilanDivision of Cardiology, Department of Medicine and the Cardiovascular Imaging Research Center, Massachusetts General Hospital and Harvard Medical School, Boston, Massachusetts.
Meredith L WallaceDepartment of Psychiatry and Department of Biostatistics, and.
Margo HudsonDepartment of Medicine, Harvard Medical School, Boston, Massachusetts.
Atul MalhotraDivision of Pulmonary, Critical Care, and Sleep Medicine, University of California, San Diego, San Diego, California.
Sanjay R PatelCenter for Sleep and Cardiovascular Outcomes Research, Department of Medicine, University of Pittsburgh, Pittsburgh, Pennsylvania.ORCID 0000-0002-9142-5172
Aristidis VevesThe Rongxiang Xu MD Center for Regenerative Therapeutics.
Brigham and Women's Hospital · USHarvard University · USBeth Israel Deaconess Medical Center · USBritish Microcirculation Society · GBCancer Research And Biostatistics · USSaad Specialist Hospital · SAUniversity of California System · USUniversity of Pittsburgh · USVita-Salute San Raffaele University · IT
Funding
Obstructive Sleep Apnea Increases Cardiovascular Risk in Type 2 DiabetesR01HL110350 · NHLBI · BETH ISRAEL DEACONESS MEDICAL CENTER · PI PATEL, SANJAY R, VEVES, ARISTIDIS · 2012 to 2016
$4.0MSingle Motor Unit Genioglossus Recordings to Understand Sleep Apnea PathogenesisR01HL085188 · NHLBI · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI MALHOTRA, ATUL · 2008 to 2018
$3.5MTraining in the Next Generation in Respiratory ScienceT32HL134632 · NHLBI · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI MALHOTRA, ATUL, POWELL, FRANK L. · 2017 to 2021
$2.1MAssessment of Upper Airway Mechanics Using Newer Electromyographic TechniquesK24HL132105 · NHLBI · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI MALHOTRA, ATUL · 2016 to 2020
$611kMentored Patient Oriented Research in Sleep and Metabolic DiseaseK24HL127307 · NHLBI · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI PATEL, SANJAY R · 2015 to 2019
$582kNHLBI NIH HHS K24 HL127307NHLBI NIH HHS K24 HL132105NHLBI NIH HHS R01 HL085188NHLBI NIH HHS R01 HL110350NHLBI NIH HHS T32 HL134632
Abstract
PubMed holds no abstract for this paper.
Indexed as
Continuous Positive Airway PressureAdultAgedCross-Sectional StudiesDiabetes Mellitus, Type 2FemaleHumansMagnetic Resonance ImagingMaleMiddle AgedPolysomnographySleep Apnea, ObstructiveTreatment OutcomeVentricular Function, LeftVentricular Function, Rightcardiovascularendotheliummetabolismobstructive sleep apneatype 2 diabetes mellitus
Identifiers
What OpenQuestion holds
Textmetadata
Read underepoch 390
Registered trials
None linked
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.