ArticleAmerican journal of physiology. Heart and circulatory physiology2020
Comparative quantification of primary mitral regurgitation by computer modeling and simulated echocardiography.
Article in American journal of physiology. Heart and circulatory physiology, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.
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Who cites it
10 citing papers in PubMed.
- Investigating the Shortcomings of the Flow Convergence Method for Quantification of Mitral Regurgitation in a Pulsatile In-Vitro Environment and with Computational Fluid Dynamics.Cardiovascular engineering and technology · 2025Article
- Guidelines for mechanistic modeling and analysis in cardiovascular research.American journal of physiology. Heart and circulatory physiology · 2024Review
- Enhancing the implantation of mechanical circulatory support devices using computational simulations.Frontiers in bioengineering and biotechnology · 2024Article
- Quantification of primary mitral regurgitation by echocardiography: A practical appraisal.Frontiers in cardiovascular medicine · 2023Review
- Clinical Impact of Computational Heart Valve Models.Materials (Basel, Switzerland) · 2022Review
- Research on Diagnosis Architecture of Cardiovascular Diseases Based on Multimedical Images.Computational and mathematical methods in medicine · 2022Article
- Quantification of regurgitation in mitral valve prolapse with automated real time echocardiographic 3D proximal isovelocity surface area: multimodality consistency and role of eccentricity index.The international journal of cardiovascular imaging · 2021Article
- Fluid-Structure Interaction Analyses of Biological Systems Using Smoothed-Particle Hydrodynamics.Biology · 2021Review
- A Comprehensive Engineering Analysis of Left Heart Dynamics After MitraClip in a Functional Mitral Regurgitation Patient.Frontiers in physiology · 2020Article
- The Impact of Self-Expandable Transcatheter Aortic Valve Replacement on Concomitant Functional Mitral Regurgitation: A Comprehensive Engineering Analysis.Structural heart : the journal of the Heart Team · 2020Article
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Authors and funding
4 authors.
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Abstract
Clinical investigations have demonstrated that mitral regurgitation (MR) quantification using echocardiography (echo) may significantly underestimate or overestimate the regurgitant volume, especially for two-dimensional (2D) echo. Computer modeling and simulated echo were conducted to evaluate the fundamental assumptions in the echo quantification of primary MR that is due to posterior mitral leaflet prolapse. The theoretical flaw of the proximal isovelocity surface area (PISA) method originates from the assumption that the MR flow rate is the product of the isovelocity surface area and aliasing velocity, which is only valid when the velocity vectors are perpendicular to the isovelocity surface. Other factors such as the Doppler angle effect, the view planes of 2D echo, and the single time instant of PISA were also analyzed. We find that the hemielliptic PISA method gives the smallest error for moderate and severe MR cases compared with other PISA methods. Compared with the PISA method, the volumetric technique (VT) is theoretically more robust. By considering correction factors that are caused by nonflat velocity profiles and the closing volume of the aortic valve, the accuracy of the VT method can be significantly improved. The corrected volumetric technique provides more accurate results compared with the PISA methods, especially for mild MR.
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