Evidence map›Paper›PMID 31922888›Full record

ArticleAmerican journal of physiology. Heart and circulatory physiology2020

Nitric oxide synthase inhibitors negatively regulate respiration in isolated rodent cardiac and brain mitochondria.

Siva S V P Sakamuri, Jared A Sperling, Wesley R Evans, Monica H Dholakia, Aaron L Albuck, Venkata N Sure, Ryousuke Satou, Ricardo Mostany, Prasad V G Katakam

Open access · bronzeAbstract read
In one paragraph

Article in American journal of physiology. Heart and circulatory physiology, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.

0numbers the graph read from it
0cells of the map it votes in
13citing papers in PubMed
2.3field-weighted citation impact, top 12% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

13 citing papers in PubMed, 23 citations in OpenAlex.

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  12. Peroxynitrite decomposition catalyst enhances respiratory function in isolated brain mitochondria.American journal of physiology. Heart and circulatory physiology · 2021
    Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 1 institution in 1 country.

Siva S V P SakamuriDepartment of Pharmacology, Tulane University School of Medicine, New Orleans, Louisiana.
Jared A SperlingDepartment of Pharmacology, Tulane University School of Medicine, New Orleans, Louisiana.
Wesley R EvansDepartment of Pharmacology, Tulane University School of Medicine, New Orleans, Louisiana.
Monica H DholakiaDepartment of Pharmacology, Tulane University School of Medicine, New Orleans, Louisiana.
Aaron L AlbuckDepartment of Pharmacology, Tulane University School of Medicine, New Orleans, Louisiana.
Venkata N SureDepartment of Pharmacology, Tulane University School of Medicine, New Orleans, Louisiana.
Ryousuke SatouDepartment of Physiology, Tulane University School of Medicine, New Orleans, Louisiana.ORCID 0000-0001-6505-9722
Ricardo MostanyDepartment of Pharmacology, Tulane University School of Medicine, New Orleans, Louisiana.ORCID 0000-0002-5379-0080
Prasad V G KatakamDepartment of Pharmacology, Tulane University School of Medicine, New Orleans, Louisiana.ORCID 0000-0002-4708-9140
Tulane University · US

Funding

Tracking & Evaluation CoreU54GM104940 · NIGMS · LSU PENNINGTON BIOMEDICAL RESEARCH CTR · PI Peter Todd Katzmarzyk · 2012 to 2026
$69.1M
Cortical Synaptic Dynamics during Learning in the Aging BrainR01AG047296 · NIA · TULANE UNIVERSITY OF LOUISIANA · PI MOSTANY, RICARDO · 2016 to 2020
$1.7M
Histone deacetylase 9 is an epigenetic suppressor of intrarenal angiotensinogen, serving as a key mechanism in angiotensinogen augmentation in hypertensionR01DK107694 · NIDDK · TULANE UNIVERSITY OF LOUISIANA · PI SATO, RYOSUKE · 2016 to 2020
$1.4M
Endothelial Expression of Neuronal Nitric Oxide SynthaseR01NS094834 · NINDS · TULANE UNIVERSITY OF LOUISIANA · PI KATAKAM, PRASAD V · 2016 to 2019
$1.3M
NIA NIH HHS R01 AG047296NIDDK NIH HHS R01 DK107694NIGMS NIH HHS U54 GM104940NINDS NIH HHS R01 NS094834
6 · The paper itself

Abstract

Nitric oxide (NO) is known to exert inhibitory control on mitochondrial respiration in the heart and brain. Evidence supports the presence of NO synthase (NOS) in the mitochondria (mtNOS) of cells; however, the functional role of mtNOS in the regulation of mitochondrial respiration is unclear. Our objective was to examine the effect of NOS inhibitors on mitochondrial respiration and protein

Indexed as

AmidinesAnimalsBrainEnzyme InhibitorsMiceMice, Inbred C57BLMitochondriaMitochondria, HeartNitric Oxide SynthaseNitric Oxide Synthase Type INitric Oxide Synthase Type IIIOrnithineOxygen ConsumptionAmidinesARL 17477Enzyme InhibitorsN(G)-iminoethylornithineNitric Oxide SynthaseNitric Oxide Synthase Type INitric Oxide Synthase Type IIINos1 protein, mouseNos3 protein, mouseOrnithineeNOSmitochondrial nitric oxide synthasemitochondrial respirationnNOSoxygen consumption rate

Identifiers

PMID31922888
PMCPMC7132325
OpenAlexW2998971830

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.