Evidence map›Paper›PMID 31922651›Full record

ArticleAmerican journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons2020

Early graft losses in paired kidney exchange: Experience from 10 years of the National Kidney Registry.

Jennifer Verbesey, Alvin G Thomas, Matt Ronin, Jennifer Beaumont, Amy Waterman, Dorry L Segev, Stuart M Flechner, Matthew Cooper

Abstract read
In one paragraph

Article in American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed.

  1. Navigating a Quandary in Kidney Exchange Programs: A Review of Donor Travel versus Organ Shipment.Transplant international : official journal of the European Society for Organ Transplantation · 2025
    Review
  2. Article
  3. The benefit to waitlist patients in a national paired kidney exchange program: Exploring characteristics of chain end living donor transplants.American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons · 2022
    Article
  4. Motivations and outcomes of compatible living donor-recipient pairs in paired exchange.American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons · 2022
    Article
  5. Article
  6. Article
  7. Ethical principles governing organ transplantation apply to paired exchange programs.American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons · 2020
    Article
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

8 authors.

Jennifer VerbeseyMedstar Georgetown Transplant Institute, Washington, District of Columbia, USA.
Alvin G ThomasDepartment of Epidemiology, University of North Carolina, Chapel Hill, North Carolina, USA.ORCID 0000-0003-4911-8192
Matt RoninNational Kidney Registry, Babylon, New York, USA.
Jennifer BeaumontTerasaki Research Institute, Los Angeles, California, USA.ORCID 0000-0002-1484-260X
Amy WatermanTerasaki Research Institute, Los Angeles, California, USA.ORCID 0000-0002-7799-0060
Dorry L SegevDepartment of Surgery, Johns Hopkins University School of Medicine, Baltimore, Maryland, USA.
Stuart M FlechnerGlickman Urological and Kidney Institute, Cleveland Clinic, Cleveland, Ohio, USA.
Matthew CooperMedstar Georgetown Transplant Institute, Washington, District of Columbia, USA.

Funding

Cardiovascular Epidemiology Training GrantT32HL007055 · NHLBI · UNIV OF NORTH CAROLINA CHAPEL HILL · PI Wayne D. Rosamond · 1986 to 2026
$10.0M
Patient Oriented Research in Solid Organ TransplantationK24AI144954 · NIAID · NEW YORK UNIVERSITY SCHOOL OF MEDICINE · PI SEGEV, DORRY L. · 2020 to 2024
$956k
Patient Oriented Research in Kidney Disease and Transplant SurgeryK24DK101828 · NIDDK · JOHNS HOPKINS UNIVERSITY · PI SEGEV, DORRY L. · 2014 to 2018
$922k
NHLBI NIH HHS T32 HL007055NIAID NIH HHS K24 AI144954NIDDK NIH HHS K24 DK101828
6 · The paper itself

Abstract

Cooperative kidney paired donation (KPD) networks account for an increasing proportion of all living donor kidney transplants in the United States. There are sparse data on the rate of primary nonfunction (PNF) losses and their consequences within KPD networks. We studied National Kidney Registry (NKR) transplants (February 14, 2009 to December 31, 2017) and quantified PNF, graft loss within 30 days of transplantation, and graft losses in the first-year posttransplant and assessed potential risk factors. Of 2364 transplants, there were 38 grafts (1.6%) lost within the first year, 13 (0.5%) with PNF. When compared to functioning grafts, there were no clinically significant differences in blood type compatibility, degree of HLA mismatch, number of veins/arteries, cold ischemia, and travel times. Of 13 PNF cases, 2 were due to early venous thrombosis, 2 to arterial thrombosis, and 2 to failure of desensitization and development of antibody-mediated rejection (AMR). Given the low rate of PNF, the NKR created a policy to allocate chain-end kidneys to recipients with PNF following event review and attributable to surgical issues of donor nephrectomy. It is expected that demonstration of low incidence of poor early graft outcomes and the presence of a "safety net" would further encourage program participation in national KPD.

Indexed as

Kidney TransplantationTissue and Organ ProcurementGraft RejectionGraft SurvivalHumansKidneyLiving DonorsRegistriesUnited Statesclinical research/practicedonors and donation: livinggraft survivalkidney transplantation: living donorkidney transplantation/nephrologyprimary nonfunction

Identifiers

PMID31922651
PMCPMC7183872

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.