ReviewJournal of experimental botany2020
FIT, a regulatory hub for iron deficiency and stress signaling in roots, and FIT-dependent and -independent gene signatures.
Review in Journal of experimental botany, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 61 papers, 1 of them a synthesis that pooled it.
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Who cites it
61 citing papers in PubMed, 1 synthesis or guideline pooled it, 137 citations in OpenAlex.
- Meta-Analysis of Iron Excess Stress in Rice: Genes and Mechanisms of Tolerance to Acidic Soil.Physiologia plantarumPooled it
- A bHLH121/URI-ANAC017-MAT1/SAM1 regulatory cascade controls iron homeostasis in Arabidopsis.The Plant journal : for cell and molecular biology · 2026Article
- From the Cosmos to the Cell: The Central Role of Iron in the Chemistry and Evolution of Life.International journal of molecular sciences · 2026Review
- Integrated physiological, element content, transcriptomic and weighted gene co-expression network analysis provide insights into the response mechanisms of Areca catechu to Zn/Fe deficiency stress.BMC plant biology · 2026Article
- CITF1 interacts with FIT and regulates copper-iron crosstalk in Arabidopsis.The Plant cell · 2026Article
- Hormonal Status and the Probable Role of Phytohormones in Response of Pea Cultivar Sparkle and Mutant E107 (Plants (Basel, Switzerland) · 2026Article
- Root cell wall plasticity in iron homeostasis: an overlooked frontier in plant nutrition.The New phytologist · 2026Review
- Expanding Iron Acquisition in Maize: Root Sector-Specific Responses and Gibberellin Regulation of Ferric and Ferrous Iron Uptake.International journal of molecular sciences · 2026Article
- Iron need attention: a review on the role of iron in plants.Frontiers in plant science · 2026Review
- "Iron" road in apple: the pathway regulated by MPK6-2-ERF4-FIT module.Plant physiology · 2025Article
- Age-dependent differential iron deficiency responses of rosette leaves during reproductive stages in Arabidopsis thaliana.Journal of experimental botany · 2025Article
- What Is Similar, What Is Different? Characterization of Mitoferrin-like Proteins fromInternational journal of molecular sciences · 2025Article
- Shedding light on iron nutrition: exploring intersections of transcription factor cascades in light and iron deficiency signaling.Journal of experimental botany · 2025Review
- Arabidopsis MEB3 functions as a vacuolar metal transporter to regulate iron accumulation in roots.Frontiers in plant science · 2025Article
- The transcription factor Dof3.6/OBP3 regulates iron homeostasis in Arabidopsis.The EMBO journal · 2025Article
- Investigating the Role of Known Arabidopsis Iron Genes in a Stress Resilient Soybean Line.International journal of molecular sciences · 2024Article
- FER-like iron deficiency-induced transcription factor (FIT) accumulates in nuclear condensates.The Journal of cell biology · 2024Article
- The small iron-deficiency-induced protein OLIVIA and its relation to the bHLH transcription factor POPEYE.PloS one · 2024Article
- AlfalfaFrontiers in plant science · 2024Article
- Article
1 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
2 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Iron (Fe) is vital for plant growth. Plants balance the beneficial and toxic effects of this micronutrient, and tightly control Fe uptake and allocation. Here, we review the role of the basic helix-loop-helix (bHLH) transcription factor FIT (FER-LIKE FE DEFICIENCY-INDUCED TRANSCRIPTION FACTOR) in Fe acquisition. FIT is not only essential, it is also a central regulatory hub in root cells to steer and adjust the rate of Fe uptake by the root in a changing environment. FIT regulates a subset of root Fe deficiency (-Fe) response genes. Based on a combination of co-expression network and FIT-dependent transcriptome analyses, we defined a set of FIT-dependent and FIT-independent gene expression signatures and co-expression clusters that encode specific functions in Fe regulation and Fe homeostasis. These gene signatures serve as markers to integrate novel regulatory factors and signals into the -Fe response cascade. FIT forms a complex with bHLH subgroup Ib transcription factors. Furthermore, it interacts with key regulators from different signaling pathways that either activate or inhibit FIT function to adjust Fe acquisition to growth and environmental constraints. Co-expression clusters and FIT protein interactions suggest a connection of -Fe with ABA responses and root cell elongation processes that can be explored in future studies.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.