Evidence map›Paper›PMID 31922354›Full record

ArticleBiotechnology progress2020

Next-generation polymerized human hemoglobins in hepatic bioreactor simulations.

Clayton Cuddington, Savannah Moses, Donald Belcher, Niral Ramesh, Andre Palmer

Open access · hybridAbstract read
In one paragraph

Article in Biotechnology progress, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.

0numbers the graph read from it
0cells of the map it votes in
11citing papers in PubMed
1.3field-weighted citation impact, top 23% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

11 citing papers in PubMed, 12 citations in OpenAlex.

  1. Polymerized human hemoglobin with low and high oxygen affinity in trauma models.Translational research : the journal of laboratory and clinical medicine · 2023
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 2 institutions in 1 country.

Clayton CuddingtonDepartment of Chemical and Biomolecular Engineering, The Ohio State University, Columbus, Ohio.ORCID 0000-0001-8739-2155
Savannah MosesDepartment of Chemical and Biomolecular Engineering, The Ohio State University, Columbus, Ohio.
Donald BelcherDepartment of Chemical and Biomolecular Engineering, The Ohio State University, Columbus, Ohio.ORCID 0000-0002-7633-6219
Niral RameshDepartment of Chemical and Biomolecular Engineering, Rice University, Houston, Texas.ORCID 0000-0001-9649-1665
Andre PalmerDepartment of Chemical and Biomolecular Engineering, The Ohio State University, Columbus, Ohio.
The Ohio State University · USRice University · US

Funding

PEGylated megahemoglobin for use as a red blood cell substituteR01HL138116 · NHLBI · OHIO STATE UNIVERSITY · PI CABRALES, PEDRO, KAUMAYA, PRAVIN T. P. · 2017 to 2020
$2.9M
Attenuating the Oxidative and Myocardial Side-Effects of Acellular HemoglobinR01HL126945 · NHLBI · OHIO STATE UNIVERSITY · PI CABRALES, PEDRO, PALMER, ANDRE FRANCIS · 2016 to 2019
$1.7M
Polymerized Hemoglobins for Facilitated Oxygen Transport in Hepatic BioreactorsR01EB021926 · NIBIB · OHIO STATE UNIVERSITY · PI BERTHIAUME, FRANCOIS, PALMER, ANDRE FRANCIS · 2016 to 2019
$1.4M
NHLBI NIH HHS R01 HL126945NHLBI NIH HHS R01 HL138116NIBIB NIH HHS R01 EB021926U.S. Department of Defense W81XWH-18-1-0059
6 · The paper itself

Abstract

Hepatic hollow fiber (HF) bioreactors can be used to provide temporary support to patients experiencing liver failure. Before being connected to the patient's circulation, cells in the bioreactor must be exposed to a range of physiological O

Indexed as

PolymerizationAnimalsBioreactorsHemoglobinsHepatocytesHumansLiverLiver FailureMolecular WeightOxygenProtein MultimerizationProtein Structure, QuaternaryHemoglobinsOxygenfluid flow modelinghemoglobin-based oxygen carrierhollow fiber bioreactorpolymerized human hemoglobinred blood cell substitute

Identifiers

PMID31922354
PMCPMC9286418
OpenAlexW2998845321

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.