Evidence map›Paper›PMID 31922310›Full record

ArticleCell proliferation2020

Recombinant adiponectin peptide promotes neuronal survival after intracerebral haemorrhage by suppressing mitochondrial and ATF4-CHOP apoptosis pathways in diabetic mice via Smad3 signalling inhibition.

Xun Wu, Jianing Luo, Haixiao Liu, Wenxing Cui, Wei Guo, Lei Zhao, Hao Guo, Hao Bai, Kang Guo, Dayun Feng and 1 more

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Cell proliferation, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 27 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
27citing papers in PubMed, 2 pooled it
1.7field-weighted citation impact, top 12% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

27 citing papers in PubMed, 2 syntheses or guidelines pooled it, 32 citations in OpenAlex.

  1. Pooled it
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  16. Role of adiponectin in osteoarthritis.Frontiers in cell and developmental biology · 2022
    Review
  17. Activation of PPARPPAR research · 2022
    Article
  18. Article
  19. Adipokines as Immune Cell Modulators in Multiple Sclerosis.International journal of molecular sciences · 2021
    Review
  20. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors at 1 institution in 1 country.

Xun WuDepartment of Neurosurgery, Tangdu Hospital, The Fourth Military Medical University, Xi'an, China.
Jianing LuoDepartment of Neurosurgery, Tangdu Hospital, The Fourth Military Medical University, Xi'an, China.
Haixiao LiuDepartment of Neurosurgery, Tangdu Hospital, The Fourth Military Medical University, Xi'an, China.
Wenxing CuiDepartment of Neurosurgery, Tangdu Hospital, The Fourth Military Medical University, Xi'an, China.
Wei GuoDepartment of Neurosurgery, Tangdu Hospital, The Fourth Military Medical University, Xi'an, China.
Lei ZhaoDepartment of Neurosurgery, Tangdu Hospital, The Fourth Military Medical University, Xi'an, China.
Hao GuoDepartment of Neurosurgery, Tangdu Hospital, The Fourth Military Medical University, Xi'an, China.
Hao BaiDepartment of Neurosurgery, Tangdu Hospital, The Fourth Military Medical University, Xi'an, China.
Kang GuoDepartment of Neurosurgery, Tangdu Hospital, The Fourth Military Medical University, Xi'an, China.
Dayun FengDepartment of Neurosurgery, Tangdu Hospital, The Fourth Military Medical University, Xi'an, China.
Yan QuDepartment of Neurosurgery, Tangdu Hospital, The Fourth Military Medical University, Xi'an, China.ORCID https://orcid.org/0000-0001-5434-7390
Air Force Medical University · CN

Funding

Chang Jiang Scholar Program of ChinaNational Natural Science Foundation of China 81571215State Key Program of National Natural Science Foundation of China 81630027
6 · The paper itself

Abstract

objectiveLow levels of adiponectin (APN), a biomarker of diabetes mellitus, have been implicated in the poor outcome of intracerebral haemorrhage (ICH). Herein, we aimed to demonstrate the neuroprotective effects of a blood-brain barrier-permeable APN peptide (APNp) on ICH injury in diabetic mice and explore the underlying mechanisms. MATERIALS AND

methodsRecombinant APNp was administrated intraperitoneally to mice with collagenase-induced ICH. Neurological deficits, brain water content and neural apoptosis were assessed. Western blotting, immunofluorescence staining, quantitative RT-PCR and transmission electron microscopy were used to determine the signalling pathways affected by APNp.

resultsAdiponectin peptide significantly alleviated neural apoptosis, neurological deficits and brain oedema following ICH in diabetic mice. Mechanistically, APNp promoted the restoration of peroxisome proliferator-activated receptor gamma coactivator (PGC)-1α related mitochondrial function and suppressed activating transcription factor 4 (ATF4)-CCAAT-enhancer-binding protein homologous protein (CHOP)-induced neural apoptosis. Furthermore, Smad3 signalling was found to play a regulatory role in this process by transcriptionally regulating the expression of PGC-1α and ATF4. APNp significantly suppressed the elevated phosphorylation and nuclear translocation of Smad3 after ICH in diabetic mice, while the protective effects of APNp on mitochondrial and ATF4-CHOP apoptosis pathways were counteracted when Smad3 was activated by exogenous transforming growth factor (TGF)-β1 treatment.

conclusionsOur study provided the first evidence that APNp promoted neural survival following ICH injury in the diabetic setting and revealed a novel mechanism by which APNp suppressed mitochondrial and ATF4-CHOP apoptosis pathways in a Smad3 dependent manner.

Indexed as

Activating Transcription Factor 4AdiponectinAnimalsApoptosisBrainCell NucleusCells, CulturedCerebral HemorrhageDiabetes Mellitus, ExperimentalMaleMiceMice, Inbred C57BLMitochondriaNeuronsPeroxisome Proliferator-Activated Receptor Gamma Coactivator 1-alphaProtein TransportActivating Transcription Factor 4AdiponectinAtf4 protein, mouseDdit3 protein, mousePeroxisome Proliferator-Activated Receptor Gamma Coactivator 1-alphaRecombinant ProteinsSmad3 ProteinSmad3 protein, mouseTranscription Factor CHOPTransforming Growth Factor beta1apoptosisdiabetes mellitusintracerebral haemorrhagerecombinant adiponectin peptideSmad3

Identifiers

PMID31922310
PMCPMC7048203
OpenAlexW2999813309

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.