Evidence map›Paper›PMID 31922301›Full record

ArticleNMR in biomedicine2020

Advanced single voxel

Gülin Öz, Dinesh K Deelchand, Jannie P Wijnen, Vladimír Mlynárik, Lijing Xin, Ralf Mekle, Ralph Noeske, Tom W J Scheenen, Ivan Tkáč, Experts' Working Group on Advanced Single Voxel 1H MRS

Open access · bronzeAbstract read
In one paragraph

Article in NMR in biomedicine, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 121 papers, 4 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
121citing papers in PubMed, 4 pooled it
12.9field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

121 citing papers in PubMed, 4 syntheses or guidelines pooled it, 187 citations in OpenAlex.

  1. Pooled it
  2. Pooled it
  3. Pooled it
  4. Pooled it
  5. Trial
  6. Article
  7. Article
  8. Article
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  10. Review
  11. Article
  12. Review
  13. Article
  14. Reduced Muscular Carnosine in Proximal Myotonic Myopathy-A PilotAnnals of clinical and translational neurology · 2026
    Article
  15. Article
  16. Neurobiology of aging · 2026
    Article
  17. Article
  18. Article
  19. Article
  20. Review

61 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 7 institutions in 6 countries.

Gülin ÖzCenter for Magnetic Resonance Research, Department of Radiology, University of Minnesota, Minneapolis, USA.ORCID https://orcid.org/0000-0002-5769-183X
Dinesh K DeelchandCenter for Magnetic Resonance Research, Department of Radiology, University of Minnesota, Minneapolis, USA.ORCID https://orcid.org/0000-0003-4266-4780
Jannie P WijnenHigh Field MR Research group, Department of Radiology, University Medical Centre Utrecht, Utrecht, the Netherlands.
Vladimír MlynárikHigh Field MR Centre, Department of Biomedical Imaging and Image-Guided Therapy, Medical University of Vienna, Vienna, Austria.
Lijing XinAnimal Imaging and Technology Core (AIT), Center for Biomedical Imaging (CIBM), École Polytechnique Fédérale de Lausanne, Lausanne, Switzerland.ORCID https://orcid.org/0000-0002-5450-6109
Ralf MekleCenter for Stroke Research Berlin (CSB), Charité Universitätsmedizin Berlin, Berlin, Germany.
Ralph NoeskeGE Healthcare, Berlin, Germany.
Tom W J ScheenenDepartment of Radiology and Nuclear Medicine, Radboud University Medical Center, Nijmegen, the Netherlands.
Ivan TkáčCenter for Magnetic Resonance Research, Department of Radiology, University of Minnesota, Minneapolis, USA.
Experts' Working Group on Advanced Single Voxel 1H MRS
University of Minnesota · USCentre d'Imagerie BioMedicale · CHCharité - Universitätsmedizin Berlin · DEErwin L. Hahn Institute for Magnetic Resonance Imaging · DEGeneral Electric (Spain) · ESMedical University of Vienna · ATUniversity Medical Center Utrecht · NL

Funding

TRD4 - Ultrahigh Field Engineering and SafetyP41EB027061 · NIBIB · UNIVERSITY OF MINNESOTA · PI Gregory John Metzger, KAMIL UGURBIL · 2019 to 2026
$11.7M
NMR Imaging and SpectroscopyP41EB015894 · NIBIB · UNIVERSITY OF MINNESOTA · PI UGURBIL, KAMIL · 2012 to 2017
$8.4M
Institutional Center Cores for Advanced NeuroimagingP30NS076408 · NINDS · UNIVERSITY OF MINNESOTA · PI UGURBIL, KAMIL · 2012 to 2020
$4.2M
Partnership for Magnetic Resonance Spectroscopy Biomarker Development-SupplementR01NS080816 · NINDS · UNIVERSITY OF MINNESOTA · PI OZ, GULIN · 2015 to 2019
$3.2M
NIBIB NIH HHS P41 EB015894NIBIB NIH HHS P41 EB027061NINDS NIH HHS P30 NS076408NINDS NIH HHS R01 NS080816
6 · The paper itself

Abstract

Conventional proton MRS has been successfully utilized to noninvasively assess tissue biochemistry in conditions that result in large changes in metabolite levels. For more challenging applications, namely, in conditions which result in subtle metabolite changes, the limitations of vendor-provided MRS protocols are increasingly recognized, especially when used at high fields (≥3 T) where chemical shift displacement errors, B

Indexed as

bodybrainchemical shift displacementmetabolitesreproducibilitysemiadiabatic LASERshimmingSPECIAL

Identifiers

PMID31922301
PMCPMC7347431
OpenAlexW2999818394

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.