ArticleResearch (Washington, D.C.)2019
Responsive Inverse Opal Scaffolds with Biomimetic Enrichment Capability for Cell Culture.
Article in Research (Washington, D.C.), 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 34 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
34 citing papers in PubMed.
- Hydrogel-Based Strategies for Liver Tissue Engineering.Chem & bio engineering · 2024Review
- Islet cell spheroids produced by a thermally sensitive scaffold: a new diabetes treatment.Journal of nanobiotechnology · 2024Article
- Microgels for Cell Delivery in Tissue Engineering and Regenerative Medicine.Nano-micro letters · 2024Review
- Construction of cardiac fibrosis for biomedical research.Smart medicine · 2023Review
- Biomimetic natural biomaterials for tissue engineering and regenerative medicine: new biosynthesis methods, recent advances, and emerging applications.Military Medical Research · 2023Review
- Reconstruction of the alveolar-capillary barrier in vitro based on a photo-responsive stretchable Janus membrane.Smart medicine · 2023Article
- Encoding microcarriers for biomedicine.Smart medicine · 2023Review
- Shape Memory Polymer Composites: 4D Printing, Smart Structures, and Applications.Research (Washington, D.C.) · 2023Review
- Microfluidic Formulation of Topological Hydrogels for Microtissue Engineering.Chemical reviews · 2022Review
- Responsive and self-healing structural color supramolecular hydrogel patch for diabetic wound treatment.Bioactive materials · 2022Article
- Dynamically Responsive Scaffolds from Microfluidic 3D Printing for Skin Flap Regeneration.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2022Article
- Shear-flow-induced graphene coating microfibers from microfluidic spinning.Innovation (Cambridge (Mass.)) · 2022Article
- Tailoring conductive inverse opal films with anisotropic elliptical porous patterns for nerve cell orientation.Journal of nanobiotechnology · 2022Article
- Recapitulating dynamic ECM ligand presentation at biomaterial interfaces: Molecular strategies and biomedical prospects.Exploration (Beijing, China) · 2022Review
- Erratum to "Responsive Inverse Opal Scaffolds with Biomimetic Enrichment Capability for Cell Culture".Research (Washington, D.C.) · 2022Article
- Emerging Theranostic Nanomaterials in Diabetes and Its Complications.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2022Review
- Review on Multicomponent Hydrogel Bioinks Based on Natural Biomaterials for Bioprinting 3D Liver Tissues.Frontiers in bioengineering and biotechnology · 2022Review
- Opportunities and challenges of hepatocellular carcinoma organoids for targeted drugs sensitivity screening.Frontiers in oncology · 2022Review
- Living Bacterial Hydrogels for Accelerated Infected Wound Healing.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2021Article
- Tailoring Materials with Specific Wettability in Biomedical Engineering.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2021Review
Corrections and comments
- Erratum issued
Authors and funding
6 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Three-dimensional (3D) porous scaffolds have a demonstrated value for tissue engineering and regenerative medicine. Inspired by the predation processes of marine predators in nature, we present new photocontrolled shrinkable inverse opal graphene oxide (GO) hydrogel scaffolds for cell enrichment and 3D culture. The scaffolds with adjustable pore sizes and morphologies were created using a GO and N-isopropylacrylamide dispersed solution as a continuous phase of microfluidic emulsions for polymerizing and replicating. Because of the interconnected porous structures and the remotely controllable volume responsiveness of the scaffolds, the suspended cells could be enriched into the inner spaces of the scaffolds through predator-like swallowing and discharging processes. Hepatocyte cells concentrated in the scaffold pores could form denser 3D spheroids more quickly via the controlled compression force caused by the shrinking of the dynamic scaffolds. More importantly, with a program of scaffold enrichment with different cells, an unprecedented 3D multilayer coculture system of endothelial-cell-encapsulated hepatocytes and fibroblasts could be generated for applications such as liver-on-a-chip and bioartificial liver. It was demonstrated that the resultant multicellular system offered significant improvements in hepatic functions, such as albumin secretion, urea synthesis, and cytochrome P450 expression. These features of our scaffolds make them highly promising for the biomimetic construction of various physiological and pathophysiological 3D tissue models, which could be used for understanding tissue level biology and
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.