ArticleEClinicalMedicine2020
A validated composite model to predict risk of curve progression in adolescent idiopathic scoliosis.
Article in EClinicalMedicine, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers, 2 of them syntheses that pooled it.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
21 citing papers in PubMed, 2 syntheses or guidelines pooled it.
- Prediction models for curve progression in adolescent idiopathic scoliosis: a systematic review with exploratory meta-analysis of discrimination.BMC musculoskeletal disorders · 2026Pooled it
- Curve type, flexibility, correction, and rotation are predictors of curve progression in patients with adolescent idiopathic scoliosis undergoing conservative treatment : a systematic review.The bone & joint journal · 2022Pooled it
- OM-sqPCR enables one-step multiplex quantification of circulating small-RNA subclasses for colorectal cancer classification.iScience · 2026Article
- A scoping review of published reviews on the use of bracing in scoliosis.Spine deformity · 2026Article
- Current insights into circulating biomarkers and their potential for predicting adolescent idiopathic scoliosis progression.Frontiers in cell and developmental biology · 2026Review
- Genome-wide association study identifiesPeerJ · 2026Article
- Factors Related to Curve Progression in Adolescent Idiopathic Scoliosis Girls at Skeletal Maturity.Healthcare (Basel, Switzerland) · 2025Article
- Assessment and Management of Adolescent Idiopathic Scoliosis: From the Perspective of a Physiatrist.Annals of rehabilitation medicine · 2025Article
- Curve Progression in Adolescent Idiopathic Scoliosis with Cobb Angles Between 40 and 50 Degrees at the Late Stage of Skeletal Growth: A Minimum 5-Year Follow-Up Study.Journal of clinical medicine · 2025Article
- Idiopathic Scoliosis Progression: Presenting Rib and Segmental Rib Index as Predictors-A Literature Review.Medical sciences (Basel, Switzerland) · 2025Review
- Predicting Progression in Adolescent Idiopathic Scoliosis at the First Visit by Integrating 2D Imaging and 1D Clinical Information.Global spine journal · 2025Article
- Prognostic model development for risk of curve progression in adolescent idiopathic scoliosis: a prospective cohort study of 127 patients.Acta orthopaedica · 2024Article
- Deep Learning-Based Prediction Model for the Cobb Angle in Adolescent Idiopathic Scoliosis Patients.Diagnostics (Basel, Switzerland) · 2024Article
- Using Electric Stimulation of the Spinal Muscles and Electromyography during Motor Tasks for Evaluation of the Role in Development and Progression of Adolescent Idiopathic Scoliosis.Journal of clinical medicine · 2024Article
- Handgrip strength assessment at baseline in addition to bone parameters could potentially predict the risk of curve progression in adolescent idiopathic scoliosis.Frontiers in pediatrics · 2023Article
- Investigation of ultrasonic soft tissue-bone reflection coefficients correlating with curve severity in children with adolescent idiopathic scoliosis.Proceedings of the Institution of Mechanical Engineers. Part H, Journal of engineering in medicine · 2022Article
- Upregulation of microRNA-96-5p is associated with adolescent idiopathic scoliosis and low bone mass phenotype.Scientific reports · 2022Article
- Predicting curve progression for adolescent idiopathic scoliosis using random forest model.PloS one · 2022Article
- An artificial intelligence powered platform for auto-analyses of spine alignment irrespective of image quality with prospective validation.EClinicalMedicine · 2022Article
- Potential Muscle-Related Biomarkers in Predicting Curve Progression to the Surgical Threshold in Adolescent Idiopathic Scoliosis-A Pilot Proteomic Study Comparing Four Non-Progressive vs. Four Progressive Patients vs. A Control Cohort.Journal of clinical medicine · 2021Article
Corrections and comments
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Authors and funding
16 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundIn adolescent idiopathic scoliosis (AIS), the continuous search for effective prognostication of significant curve progression at the initial clinical consultation to inform decision for timely treatment and to avoid unnecessary overtreatment remains a big challenge as evidence of the multifactorial etiopathogenic nature is increasingly reported. This study aimed to formulate a composite model composed of clinical parameters and circulating markers in the prediction of curve progression.
methodThis is a two-phase study consisting of an exploration cohort (120 AIS, mean Cobb angle of 25°± 8.5 at their first clinical visit) and a validation cohort (51 AIS, mean Cobb angle of 23° ± 5.0° at the first visit). Patients with AIS were followed-up for a minimum of six years to formulate a composite model for prediction. At the first visit, clinical parameters were collected from routine clinical practice, and circulating markers were assayed from blood. FINDING: We constructed the composite predictive model for curve progression to severe Cobb angle > 40° with a high HR of 27.9 (95% CI of 6.55 to 119.16). The area under curve of the composite model is higher than that of individual parameters used in current clinical practice. The model was validated by an independent cohort and achieved a sensitivity of 72.7% and a specificity of 90%.
interpretationThis is the first study proposing and validating a prognostic composite model consisting of clinical and circulating parameters which could quantitatively evaluate the probability of curve progression to a severe curvature in AIS at the initial consultation. Further validation in clinic will facilitate application of composite model in assisting objective clinical decision.
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