ArticleAlzheimer's & dementia (New York, N. Y.)2019
A blood-based nutritional risk index explains cognitive enhancement and decline in the multidomain Alzheimer prevention trial.
Article in Alzheimer's & dementia (New York, N. Y.), 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. It is linked to trial NCT01953705 (Omega 3 PUFA for the Vascular Component of Age-related Cognitive Decline), which is not on this map. Cited by 16 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Omega 3 PUFA for the Vascular Component of Age-related Cognitive Decline
Who cites it
16 citing papers in PubMed.
- Twelve Weeks of Additional Fish Intake Improves the Cognition of Cognitively Intact, Resource-Limited Elderly People: A Randomized Control Trial.The journal of nutrition, health & aging · 2022Trial
- Omega-3 Supplementation for the Prevention of Cognitive Decline in Older Adults: Does It Depend on Homocysteine Levels?The journal of nutrition, health & aging · 2022Trial
- Metabolomic signatures of hypocaloric dietary interventions associate with breast cancer risk in the Nurses' Health Study II.medRxiv : the preprint server for health sciences · 2025Article
- Concurrent nutrient deficiencies are associated with dementia incidence.Alzheimer's & dementia : the journal of the Alzheimer's Association · 2024Article
- Nutritional metabolism and cerebral bioenergetics in Alzheimer's disease and related dementias.Alzheimer's & dementia : the journal of the Alzheimer's Association · 2023Review
- Combining reinforcement learning and virtual reality in mild neurocognitive impairment: a new usability assessment on patients and caregivers.Frontiers in aging neuroscience · 2023Article
- Docosahexaenoic Acid Ameliorates Contextual Fear Memory Deficits in the Tg2576 Alzheimer's Disease Mouse Model: Cellular and Molecular Correlates.Pharmaceutics · 2022Article
- How Alpha Linolenic Acid May Sustain Blood-Brain Barrier Integrity and Boost Brain Resilience against Alzheimer's Disease.Nutrients · 2022Article
- Nutrition state of science and dementia prevention: recommendations of the Nutrition for Dementia Prevention Working Group.The lancet. Healthy longevity · 2022Article
- Pathways explaining racial/ethnic disparities in incident all-cause and Alzheimer's disease dementia among older US men and women.Alzheimer's & dementia (New York, N. Y.) · 2022Article
- A 1-year randomized controlled trial of a nutritional blend to improve nutritional biomarkers and prevent cognitive decline among community-dwelling older adults: The Nolan Study.Alzheimer's & dementia (New York, N. Y.) · 2022Article
- Vitamin B12 and Folate Status in Cognitively Healthy Older Adults and Associations with Cognitive Performance.The journal of nutrition, health & aging · 2021Article
- Associations Between Nutritional Deficits and Physical Performance in Community-Dwelling Older Adults.Frontiers in nutrition · 2021Article
- Dietary Wheat Amylase Trypsin Inhibitors Impact Alzheimer's Disease Pathology in 5xFAD Model Mice.International journal of molecular sciences · 2020Article
- LDL cholesterol and uridine levels in blood are potential nutritional biomarkers for clinical progression in Alzheimer's disease: The NUDAD project.Alzheimer's & dementia (Amsterdam, Netherlands) · 2020Article
- Mechanisms Underlying Biological Effects of Cruciferous Glucosinolate-Derived Isothiocyanates/Indoles: A Focus on Metabolic Syndrome.Frontiers in nutrition · 2020Review
Corrections and comments
- Erratum issuedErratum.2020
Authors and funding
12 authors.
Funding
Abstract
introductionMultinutrient approaches may produce more robust effects on brain health through interactive qualities. We hypothesized that a blood-based nutritional risk index (NRI) including three biomarkers of diet quality can explain cognitive trajectories in the multidomain Alzheimer prevention trial (MAPT) over 3-years.
methodsThe NRI included erythrocyte n-3 polyunsaturated fatty acids (n-3 PUFA 22:6n-3 and 20:5n-3), serum 25-hydroxyvitamin D, and plasma homocysteine. The NRI scores reflect the number of nutritional risk factors (0-3). The primary outcome in MAPT was a cognitive composite
resultsEighty percent had at lease one nutritional risk factor for cognitive decline (NRI ≥1: 573 of 712). Participants presenting without nutritional risk factors (NRI=0) exhibited cognitive enhancement ( DISCUSSION: Identifying and addressing these well-established nutritional risk factors may reduce age-related cognitive decline in older adults; an observation that warrants further study.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.