Evidence map›Paper›PMID 31921871›Full record

ArticleFrontiers in medicine2019

Refractory Epstein-Barr Virus (EBV)-Related Post-transplant Lymphoproliferative Disease: Cure by Combined Brentuximab Vedotin and Allogeneic EBV-Specific T-Lymphocytes.

Thomas Mika, Katharina Strate, Swetlana Ladigan, Clemens Aigner, Uwe Schlegel, Iris Tischoff, Sabine Tischer-Zimmermann, Britta Eiz-Vesper, Britta Maecker-Kolhoff, Roland Schroers

Open access · goldAbstract readCase Reports
In one paragraph

Article in Frontiers in medicine, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.

0numbers the graph read from it
0cells of the map it votes in
13citing papers in PubMed
1.6field-weighted citation impact, top 14% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

13 citing papers in PubMed, 27 citations in OpenAlex.

  1. Article
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  5. Review
  6. Article
  7. Review
  8. Review
  9. Adoptive T-Cell Therapy for Epstein-Barr Virus-Related Lymphomas.Journal of clinical oncology : official journal of the American Society of Clinical Oncology · 2021
    Review
  10. Review
  11. Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 3 institutions in 1 country.

Thomas MikaDepartment of Medicine, Hematology and Oncology, Ruhr-University Bochum, Bochum, Germany.
Katharina StrateDepartment of Medicine, Hematology and Oncology, Ruhr-University Bochum, Bochum, Germany.
Swetlana LadiganDepartment of Medicine, Hematology and Oncology, Ruhr-University Bochum, Bochum, Germany.
Clemens AignerDepartment of Thoracic Surgery, Ruhrlandklinik, University Hospital Essen, Essen, Germany.
Uwe SchlegelDepartment of Neurology, Ruhr-University Bochum, Bochum, Germany.
Iris TischoffDepartment of Pathology, Ruhr-University Bochum, Bochum, Germany.
Sabine Tischer-ZimmermannInstitute for Transfusion Medicine, Hannover Medical School, Hanover, Germany.
Britta Eiz-VesperInstitute for Transfusion Medicine, Hannover Medical School, Hanover, Germany.
Britta Maecker-KolhoffDepartment of Pediatric Hematology and Oncology, Hannover Medical School, Hanover, Germany.
Roland SchroersDepartment of Medicine, Hematology and Oncology, Ruhr-University Bochum, Bochum, Germany.
Ruhr University Bochum · DEMedizinische Hochschule Hannover · DERuhrlandklinik · DE

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Post-transplant lymphoproliferative disease (PTLD) represents a serious complication following allogeneic hematopoietic stem cell transplantation (alloHSCT). Previously, survival rates of PTLD have improved due to the introduction of rituximab. However, reports on curative management of refractory PTLD are scarce. Today, there is no consensus how to treat rituximab-refractory PTLD, especially in highly aggressive disease. Here, we describe successful management of refractory EBV-associated PTLD, specifically DLBCL, with combined brentuximab vedotin and third-party EBV-specific T-cells in a multidisciplinary treatment approach.

Indexed as

aggressive lymphomaalloHSCTbrentuximab vedotin (BV)PTLDthird-party EBV-specific T-lymphocytes

Identifiers

PMID31921871
PMCPMC6930172
OpenAlexW2996278180

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.