ReviewFrontiers in pediatrics2019
Genetics and Gene-Environment Interactions in Childhood and Adult Onset Asthma.
Review in Frontiers in pediatrics, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 47 papers, 1 of them a synthesis that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
47 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Prevalence and risk factors for asthma in East Africa: a systematic review and meta-analysis.BMC pediatrics · 2026Pooled it
- A Narrative Review of Gene-Environment Interactions in Pediatric Pulmonology.Pediatric pulmonology · 2026Review
- Interactive Effects of Genetic Susceptibility and Early-Life Tobacco Smoke Exposure on the Asthma-Eczema Complex Phenotype in Children: 6-Year Follow-Up Case-Control Study.International journal of molecular sciences · 2025Article
- Gene-Air Pollution Interaction and Diversity of Genetic Sampling: The Southern California Children's Health Study.Genetic epidemiology · 2025Article
- Ethical, Legal, and Social Implications of Gene-Environment Interaction Research.Genetic epidemiology · 2025Review
- Characterisation of C-C Ligand 7 (CCL7) as Asthma Genetic Marker in Pigtailed Monkey.Tropical life sciences research · 2024Article
- Genetics of chronic respiratory disease.Nature reviews. Genetics · 2024Review
- Association between dietary carotenoid intakes and the risk of asthma in children and adolescents: evidence from the National Health and Nutrition Examination Survey 2007-2016.Translational pediatrics · 2024Article
- A Comprehensive Look at the Development of Asthma in Children.Children (Basel, Switzerland) · 2024Review
- Higher risk of osteoporosis in adult-onset asthma than childhood-onset asthma: from genetic and prospective evidence.Osteoporosis international : a journal established as result of cooperation between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA · 2024Article
- Analytical challenges in omics research on asthma and allergy: A National Institute of Allergy and Infectious Diseases workshop.The Journal of allergy and clinical immunology · 2024Article
- The Association between Vitamin D, Interleukin-4, and Interleukin-10 Levels and CD23+ Expression with Bronchial Asthma in Stunted Children.Biomedicines · 2023Article
- Metabolomics Applied to Pediatric Asthma: What Have We Learnt in the Past 10 Years?Children (Basel, Switzerland) · 2023Article
- Article
- Zinc finger protein 33B demonstrates sex interaction with atopy-related markers in childhood asthma.The European respiratory journal · 2023Article
- Interleukin-4 (C590T) Gene Polymorphism in Association with Asthma Severity.Journal of asthma and allergy · 2023Article
- Editorial: Difficult and severe asthma in children, volume II.Frontiers in pediatrics · 2023Article
- The role of gene-ambient air pollution interactions in paediatric asthma.European respiratory review : an official journal of the European Respiratory Society · 2022Review
- Article
- Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
2 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Asthma is a heterogeneous disease that results from the complex interaction between genetic factors and environmental exposures that occur at critical periods throughout life. It seems plausible to regard childhood-onset and adult-onset asthma as different entities, each with a different pathophysiology, trajectory, and outcome. This review provides an overview about the role of genetics and gene-environment interactions in these two conditions. Looking at the genetic overlap between childhood and adult onset disease gives one window into whether there is a correlation, as well as to mechanism. A second window is offered by the genetics of the relationship between each type of asthma and other phenotypes e.g., obesity, chronic obstructive pulmonary disease (COPD), atopy, vitamin D levels, and inflammatory and immune status; and third, the genetic-specific responses to the many environmental exposures that influence risk throughout life, and particularly those that occur during early-life development. These represent a large number of possible combinations of genetic and environmental factors, at least 150 known genetic loci
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.