Evidence map›Paper›PMID 31921621›Full record

ArticleFrontiers in oncology2019

Genetic Variation in CCL5 Signaling Genes and Triple Negative Breast Cancer: Susceptibility and Prognosis Implications.

Jingxuan Shan, Aziz Chouchane, Younes Mokrab, Mohamad Saad, Salha Boujassoum, Rosalyn W Sayaman, Elad Ziv, Noureddine Bouaouina, Yasmine Remadi, Sallouha Gabbouj and 4 more

Open access · goldAbstract read
In one paragraph

Article in Frontiers in oncology, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
8citing papers in PubMed, 1 pooled it
0.8field-weighted citation impact, top 24% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

8 citing papers in PubMed, 1 synthesis or guideline pooled it, 15 citations in OpenAlex.

  1. Pooled it
  2. Article
  3. Review
  4. The Relationship ofJournal of clinical medicine · 2023
    Article
  5. Review
  6. Article
  7. Article
  8. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

14 authors at 9 institutions in 4 countries.

Jingxuan ShanDepartment of Genetic Medicine, Weill Cornell Medicine, New York, NY, United States.
Aziz ChouchaneFaculta di Medicina e Chirurgia, Universita Cattolica del Sacro Cuero, Rome, Italy.
Younes MokrabTranslational Genetics and Bioinformatics Section, Research Division, Sidra Medicine, Doha, Qatar.
Mohamad SaadQatar Computing Research Institute, Hamad Bin Khalifa University, Doha, Qatar.
Salha BoujassoumDepartment of Medical Oncology, National Center for Cancer Care and Research, Hamad Medical Corporation, Doha, Qatar.
Rosalyn W SayamanDepartment of Population Sciences, City of Hope, Duarte, CA, United States.
Elad ZivHelen Diller Family Comprehensive Cancer Center at UCSF, San Francisco, CA, United States.
Noureddine BouaouinaService de Cancérologie Radiothérapie, CHU Farhat Hached, Sousse, Tunisia.
Yasmine RemadiLaboratoire d'Immuno-Oncologie Moléculaire, Faculté de Médecine de Monastir, Université de Monastir, Monastir, Tunisia.
Sallouha GabboujLaboratoire d'Immuno-Oncologie Moléculaire, Faculté de Médecine de Monastir, Université de Monastir, Monastir, Tunisia.
Jessica RoelandsTumor Biology Section, Research Division, Sidra Medicine, Doha, Qatar.
Xiaojing MaDepartment of Microbiology and Immunology, Weill Cornell Medicine, New York, NY, United States.
Davide BedognettiTumor Biology Section, Research Division, Sidra Medicine, Doha, Qatar.
Lotfi ChouchaneDepartment of Genetic Medicine, Weill Cornell Medicine, New York, NY, United States.
Cornell University · USUniversity of Monastir · TNHamad bin Khalifa University · QAHôpital Farhat Hached · TNNational Center for Cancer Care and Research · QAUCSF Helen Diller Family Comprehensive Cancer Center · USUniversità Cattolica del Sacro Cuore · ITUniversity of California, San Francisco · USWeill Cornell Medicine · US

Funding

Cancer Metabolism Training ProgramT32CA221709 · NCI · BECKMAN RESEARCH INSTITUTE/CITY OF HOPE · PI David K. Ann, Victoria L. Seewaldt · 2018 to 2026
$1.8M
NCI NIH HHS T32 CA221709
6 · The paper itself

Abstract

Triple-negative breast cancer (TNBC) accounts for ~15-20% of breast cancer (BC) and has a higher rate of early relapse and mortality compared to other subtypes. The Chemokine (C-C motif) ligand 5 (CCL5) and its signaling pathway have been linked to TNBC. We aimed to investigate the susceptibility and prognostic implications of genetic variation in CCL5 signaling genes in TNBC in the present study. We characterized variants in

Indexed as

CCL5CCL5 signaling genesprognosissusceptibilitytriple negative breast cancer

Identifiers

PMID31921621
PMCPMC6915105
OpenAlexW2988531462

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.