Evidence map›Paper›PMID 31921546›Full record

ReviewChemistryOpen2020

Surface Modification with Control over Ligand Density for the Study of Multivalent Biological Systems.

Daniele Di Iorio, Jurriaan Huskens

Abstract readReview
In one paragraph

Review in ChemistryOpen, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.

0numbers the graph read from it
0cells of the map it votes in
14citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

14 citing papers in PubMed.

  1. Article
  2. Article
  3. Review
  4. Article
  5. Review
  6. Article
  7. Article
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  9. Article
  10. Article
  11. Review
  12. Article
  13. Review
  14. Binding Revisited-Avidity in Cellular Function and Signaling.Frontiers in molecular biosciences · 2020
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors.

Daniele Di IorioMolecular NanoFabrication group MESA+ Institute for Nanotechnology, University of Twente, Enschede, The Netherlands.ORCID http://orcid.org/0000-0002-9672-9773
Jurriaan HuskensMolecular NanoFabrication group MESA+ Institute for Nanotechnology, University of Twente, Enschede, The Netherlands.ORCID http://orcid.org/0000-0002-4596-9179

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

In the study of multivalent interactions at interfaces, as occur for example at cell membranes, the density of the ligands or receptors displayed at the interface plays a pivotal role, affecting both the overall binding affinities and the valencies involved in the interactions. In order to control the ligand density at the interface, several approaches have been developed, and they concern the functionalization of a wide range of materials. Here, different methods employed in the modification of surfaces with controlled densities of ligands are being reviewed. Examples of such methods encompass the formation of self-assembled monolayers (SAMs), supported lipid bilayers (SLBs) and polymeric layers on surfaces. Particular emphasis is given to the methods employed in the study of different types of multivalent biological interactions occurring at the functionalized surfaces and their working principles.

Indexed as

Cell MembraneClick ChemistryLigandsLipid BilayersPolymersProteinsSuccinimidesSurface PropertiesLigandsLipid BilayersPolymersProteinsSuccinimidesinterfacesligand densitymonolayersmultivalencysurfaces

Identifiers

PMID31921546
PMCPMC6948118

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.