Evidence map›Paper›PMID 31921482›Full record

ReviewJournal of sport and health science2020

Updated overview on interplay between physical exercise, neurotrophins, and cognitive function in humans.

Giuseppe Lippi, Camilla Mattiuzzi, Fabian Sanchis-Gomar

2 registry-linked trialsOpen access · diamondAbstract readReview
PubMed Full text at PMC Publisher
In one paragraph

Review in Journal of sport and health science, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to 2 registered trials, which are not on this map. Cited by 47 papers.

0numbers the graph read from it
0cells of the map it votes in
47citing papers in PubMed
3.5field-weighted citation impact, top 7% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT04944251 nacompletednot on this map

Exercise in Persons With Multiple Sclerosis

TypeinterventionalSponsorEge UniversityRan2019 to 2020Enrolled43ConditionsMultiple Sclerosis, Exercise Intervention, Neuro-Degenerative DiseaseArmsRegular Exercise
NCT07104708 nanot yet recruitingnot on this mapstarted 2025, after this paper: background citation

Effects of Systematic Exercise Training on Core Symptoms, Executive Function and Brain Function in Children With ASD

TypeinterventionalSponsorChen LiRan2025 to 2028Enrolled70ConditionsAutism Spectrum DisorderArmsThe Child-Parent- Trainer exercise program, The regular physical training
3 · Its place in the literature

Who cites it

47 citing papers in PubMed, 90 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors at 2 institutions in 2 countries.

Giuseppe LippiSection of Clinical Biochemistry, University of Verona, Verona 37129, Italy.
Camilla MattiuzziService of Clinical Governance, Provincial Agency for Social and Sanitary Services, Trento 38123, Italy.
Fabian Sanchis-GomarDepartment of Physiology, Faculty of Medicine, University of Valencia and INCLIVA Biomedical Research Institute, Valencia 46010, Spain.
INCLIVA Health Research Institute · ESUniversity of Verona · IT

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The many important benefits of physical exercise also encompass maintenance or improvement of cognitive functions. Among the various mechanisms underlying the association between physical exercise and brain health, recent evidence attests that neurotrophin receptor signaling may have an important role, because the activation of this pathway leads to growth and differentiation of new neurons and synapses, supports axonal and dendritic growth, fosters synaptic plasticity, and preserves survival of existing neurons. In this review of published evidence, we highlight that a positive relationship exists between physical exercise and circulating brain-derived neurotrophic factor levels and that the postexercise variation of this molecule is associated with improvement of neurocognitive functioning. Less clear evidence has instead been published for other neurotrophins, such as nerve growth factor, neurotrophin-3, and neurotrophin-4. Overall, promotion of adequate volumes and intensities of physical exercise (i.e., approximately 3 months of moderate-intensity aerobic exercise, with 2-3 sessions/week lasting not less than 30 min) may hence be regarded as an inexpensive and safe strategy for boosting brain-derived neurotrophic factor release, thus preserving or restoring cognitive functions.

Indexed as

Brain-Derived Neurotrophic FactorCognitionExerciseHumansNerve Growth FactorsNerve Tissue ProteinsNeurotrophin 3Receptors, Nerve Growth FactorBDNF protein, humanBrain-Derived Neurotrophic FactorNerve Growth FactorsNerve Tissue ProteinsNeurotrophin 3neurotrophin 4NGFR protein, humanNTF3 protein, humanReceptors, Nerve Growth FactorCognitive functionNeurotrophinsPhysical exerciseSport

Identifiers

PMID31921482
PMCPMC6943756
OpenAlexW2971926135

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.