ArticleJournal of intensive care2020
Circadian disruption of core body temperature in trauma patients: a single-center retrospective observational study.
Article in Journal of intensive care, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.
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Who cites it
10 citing papers in PubMed.
- Establishment of a nomogram for early risk prediction of severe trauma in primary medical institutions: A multi-center study.Chinese journal of traumatology = Zhonghua chuang shang za zhi · 2025Article
- Critical illness-related corticosteroid insufficiency: latest pathophysiology and management guidelines.Acute and critical care · 2024Article
- Hot climate, hot koalas: the role of weather, behaviour and disease on thermoregulation.Conservation physiology · 2024Article
- Diurnal rhythms of wrist temperature are associated with future disease risk in the UK Biobank.Nature communications · 2023Article
- Diurnal rhythmicity of wearable device-measured wrist temperature predicts future disease incidence in the UK Biobank.Research square · 2023Article
- Prevalence and risk factors of sub-health and circadian rhythm disorder of cortisol, melatonin, and temperature among Chinese midwives.Frontiers in public health · 2023Article
- A Tangled Threesome: Circadian Rhythm, Body Temperature Variations, and the Immune System.Biology · 2021Review
- Adolescent Development of Biological Rhythms in Female Rats: Estradiol Dependence and Effects of Combined Contraceptives.Frontiers in physiology · 2021Article
- Fever Time Series Analysis Using Slope Entropy. Application to Early Unobtrusive Differential Diagnosis.Entropy (Basel, Switzerland) · 2020Article
- For Whom the Clock Ticks: Clinical Chronobiology for Infectious Diseases.Frontiers in immunology · 2020Review
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11 authors.
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Abstract
backgroundCircadian clock alterations were poorly reported in trauma patients, although they have a critical role in human physiology. Core body temperature is a clinical variable regulated by the circadian clock. Our objective was to identify the circadian temperature disruption in trauma patients and to determine whether these disruptions were associated with the 28-day mortality rate.
methodsA retrospective and observational single-center cohort study was conducted. All adult severe trauma patients admitted to the intensive care unit of Aix Marseille University, North Hospital, from November 2013 to February 2018, were evaluated. The variations of core body temperature for each patient were analyzed between days 2 and 3 after intensive care unit admission. Core body temperature variations were defined by three parameters: mesor, amplitude, and period. A logistic regression model was used to determine the variables influencing these three parameters. A survival analysis was performed assessing the association between core body temperature rhythm disruption and 28-day mortality rate. A post hoc subgroup analysis focused on the patients with head trauma.
resultsAmong the 1584 screened patients, 248 were included in this study. The period differed from 24 h in 177 (71%) patients. The mesor value (°C) was associated with body mass index and ketamine use. Amplitude (°C) was associated with ketamine use only. The 28-day mortality rate was 18%. For all trauma patients, age, body mass index, intracranial hypertension, and amplitude were independent risk factors. The patients with a mesor value < 36.9 °C (
conclusionsOur results highlight an association between core body temperature circadian alteration and 28-day mortality rate. This association was more pronounced in the head trauma patients than in the non-head trauma patients. Further studies are needed to show a causal link and consider possible interventions.
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