Evidence map›Paper›PMID 31921396›Full record

ReviewComputational and structural biotechnology journal2019

Microbiota-gut-brain axis and toll-like receptors in Alzheimer's disease.

Caixiu Lin, Shuai Zhao, Yueli Zhu, Ziqi Fan, Jing Wang, Baorong Zhang, Yanxing Chen

Open access · goldAbstract readReview
PubMed Full text at PMC Publisher
In one paragraph

Review in Computational and structural biotechnology journal, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 40 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
40citing papers in PubMed, 2 pooled it
4.4field-weighted citation impact, top 4% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

40 citing papers in PubMed, 2 syntheses or guidelines pooled it, 87 citations in OpenAlex.

  1. Pooled it
  2. Pooled it
  3. Trial
  4. Review
  5. Review
  6. Article
  7. Article
  8. Review
  9. Article
  10. Review
  11. Review
  12. Review
  13. Review
  14. Article
  15. Necrotizing Enterocolitis and the Preterm Infant Microbiome.Advances in experimental medicine and biology · 2024
    Review
  16. Review
  17. Review
  18. Review
  19. Review
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 2 institutions in 1 country.

Caixiu LinDepartment of Neurology, The Second Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou, China.
Shuai ZhaoDepartment of Neurology, The Second Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou, China.
Yueli ZhuDepartment of Neurology, The Second Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou, China.
Ziqi FanDepartment of Neurology, The Second Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou, China.
Jing WangDepartment of Geriatric, The Second Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou, China.
Baorong ZhangDepartment of Neurology, The Second Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou, China.
Yanxing ChenDepartment of Neurology, The Second Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou, China.
Second Affiliated Hospital of Zhejiang University · CNHangzhou First People's Hospital · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Alzheimer's disease (AD) is a multifactorial disease which involves both the periphery and central nervous system (CNS). It has been recently recognized that gut microbiota interacts with the gut and brain (microbiota-gut-brain axis), contributing to the pathogenesis of neurodegenerative diseases, such as AD. Dysbiosis of gut microbiota can induce increased intestinal permeability and systemic inflammation, which may lead to the development of AD pathologies and cognitive impairment via the neural, immune, endocrine, and metabolic pathways. Toll-like receptors (TLRs) play an important role in the innate immune system via recognizing microbes-derived pathogens and initiating the inflammatory process. TLRs have also been found in the brain, especially in the microglia, and have been indicated in the development of AD. In this review, we summarized the relationship between microbiota-gut-brain axis and AD, as well as the complex role of TLRs in AD. Intervention of the gut microbiota or modulation of TLRs properly might emerge as promising preventive and therapeutic strategies for AD.

Indexed as

AgingAlzheimer’s diseaseDysbiosisInflammationMicrobiota-gut-brain axisToll-like receptors

Identifiers

PMID31921396
PMCPMC6944716
OpenAlexW2981755996

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.