Evidence map›Paper›PMID 31921371›Full record

ArticleEuropean review of aging and physical activity : official journal of the European Group for Research into Elderly and Physical Activity2020

Effect of 9 weeks continuous vs. interval aerobic training on plasma BDNF levels, aerobic fitness, cognitive capacity and quality of life among seniors with mild to moderate Alzheimer's disease: a randomized controlled trial.

Lievyn Enette, Thomas Vogel, Sylvie Merle, Anna-Gaelle Valard-Guiguet, Nathalie Ozier-Lafontaine, Remi Neviere, Claudia Leuly-Joncart, Jean Luc Fanon, Pierre Olivier Lang

Registry-linked trialAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in European review of aging and physical activity : official journal of the European Group for Research into Elderly and Physical Activity, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT02968875 (Alzheimer's Disease and Physiological, Cognitive Function and BDNF Levels of Plasma Adaptation After Exercise Training), which is not on this map. Cited by 46 papers, 14 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
46citing papers in PubMed, 14 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT02968875 nacompletednot on this map

Alzheimer's Disease and Physiological, Cognitive Function and BDNF Levels of Plasma Adaptation After Exercise Training

TypeinterventionalSponsorUniversity Hospital Center of MartiniqueRan2015 to 2018Enrolled54ConditionsAlzheimer's DiseaseArmsEndurance Training, therapeutic education meetings
3 · Its place in the literature

Who cites it

46 citing papers in PubMed, 14 syntheses or guidelines pooled it.

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  5. The effect of exercise on the improvement of verbal fluency, spatial working memory, and the three major executive functions in elderly alzheimer's patients: a systematic review and meta-analysis.Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology · 2025
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Lievyn Enette1Research Laboratory Mitochondria, Oxidative stress and muscle resistance (MSP, EA-3072), Department of Physiology, Faculty of Medicine, Strasbourg University, Résidence La Yole, bat. B L'Etang Z'abricot, 97200 Strasbourg, France.ORCID https://orcid.org/0000-0002-1752-7269
Thomas Vogel1Research Laboratory Mitochondria, Oxidative stress and muscle resistance (MSP, EA-3072), Department of Physiology, Faculty of Medicine, Strasbourg University, Résidence La Yole, bat. B L'Etang Z'abricot, 97200 Strasbourg, France.
Sylvie MerleMethodology and biostatistics Unit (DRCI), University Hospital Centre of Martinique, Fort de France, France.
Anna-Gaelle Valard-GuiguetThe Caribbean reference center for rare neuromuscular and neurologic diseases (CeRCa), University Hospital Centre of Martinique, Fort de France, France.
Nathalie Ozier-LafontaineDepartment of Functional Exploration and Non-Invasive Cardiology, University Hospital Centre of Martinique, Fort de France, France.
Remi NeviereDepartment of cardiology, University Hospital Centre of Martinique, Fort de France, France.
Claudia Leuly-JoncartDepartment of Geriatric and Gerontology, University Hospital Centre of Martinique, Fort de France, France.
Jean Luc FanonDepartment of Geriatric and Gerontology, University Hospital Centre of Martinique, Fort de France, France.
Pierre Olivier LangClinic of Montchoisi, Lausanne, Switzerland.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundEvidence suggests that aerobic-type training confers physical benefits and appears to contribute positively to brain health. This study aims to compare the effect of 9-weeks continuous (CAT) to interval aerobic training (IAT) on brain derived neurotrophic factor (BDNF) plasma level, aerobic fitness, cognitive performance, and quality of life among senior with Alzheimer's disease (AD).

methods52 participants were randomly allocated into three groups (CAT

resultsNo significant change was measured in terms of plasma BDNF level and cognitive performance after interventions, in all groups compared to baseline. After 9 weeks, CAT and IAT significantly improved aerobic fitness parameters compared to controls (METs: + 0.6 and + 1.0 vs. + 0.4; MTP: + 16 watts and + 20 watts vs. + 10 watts; and functional capacities (6MWT: + 22 m and + 31 m vs. -40 m). Compared to controls, QoL-AD after CAT was improved (+ 2 points;

conclusionsNeither aerobic exercise modalities significantly modified plasma BDNF levels and cognitive performances. CAT and IAT enhanced aerobic fitness and functional capacities in AD patients and CAT their QoL.

trial registrationClinicalTrials.gov website (NCT02968875); registration date: 7 September 2016. "Retrospectively registered".

Indexed as

Aerobic exercise, aerobic fitness, BDNF, Alzheimer’s disease, cognitive performance, older adults

Identifiers

PMID31921371
PMCPMC6945614

What OpenQuestion holds

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Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.