GuidelineWorld journal of emergency surgery : WJES2020
Perforated and bleeding peptic ulcer: WSES guidelines.
Guideline in World journal of emergency surgery : WJES, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT06484699 (Open Versus Laparoscopic Repair of Perforated Peptic Ulcer in Sohag), which is not on this map. Cited by 156 papers, 9 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Open Versus Laparoscopic Repair of Perforated Peptic Ulcer in Sohag
Who cites it
156 citing papers in PubMed, 9 syntheses or guidelines pooled it, 339 citations in OpenAlex.
- Advances in standardized diagnosis and management of pediatric gastrointestinal bleeding.World journal of pediatrics : WJP · 2025Pooled it
- Advances in diagnostic techniques for eosinophilic esophagitis: a systematic review of emerging noninvasive methods.European journal of medical research · 2025Pooled it
- Prevalence and patterns of peptic ulcer disease in Africa: a systematic review and meta-analysis.BMC gastroenterology · 2025Pooled it
- Vonoprazan vs. Proton Pump Inhibitors for Treatment and Prevention of Gastric and/or Duodenal Ulcers: A Systematic Review with Meta-Analysis.Digestive diseases and sciences · 2024Pooled it
- Erythromycin prior to endoscopy for acute upper gastrointestinal haemorrhage.The Cochrane database of systematic reviews · 2023Pooled it
- Operative management of acute abdomen after bariatric surgery in the emergency setting: the OBA guidelines.World journal of emergency surgery : WJES · 2022Guideline
- Robotic surgery in emergency setting: 2021 WSES position paper.World journal of emergency surgery : WJES · 2022Pooled it
- Inguinoscrotal hernias containing stomach: risk of emergency presentation.Annals of the Royal College of Surgeons of England · 2021Pooled it
- The management of surgical patients in the emergency setting during COVID-19 pandemic: the WSES position paper.World journal of emergency surgery : WJES · 2021Guideline
- Short-term outcome following postoperative enhanced recovery implementation in patients with perforated peptic ulcer.European journal of medical research · 2025Trial
- Primary versus delayed primary skin closure in operated patients due to perforated peptic ulcer disease: a randomized controlled clinical trial.Langenbeck's archives of surgery · 2022Trial
- Duodenal perforation masquerading as an intra-abdominal abscess: successful management with pedicled falciformopexy.Journal of surgical case reports · 2026Article
- Component-Level Prognostic Evaluation of Clinical, Inflammatory, and Renal-Protein Markers for 30-Day Mortality in Older Patients with Perforated Peptic Ulcer.Journal of clinical medicine · 2026Article
- Temporal trends and demographic disparities in gastric ulcer mortality in the United States: a population-based study, 1999-2020.Annals of medicine and surgery (2012) · 2026Article
- Perforated duodenal tuberculosis with pancreaticobiliary disruption requiring salvage pancreaticoduodenectomy: a case report.Journal of surgical case reports · 2026Article
- Multifocal cellulitis and polymicrobial infection in a patient with a perforated duodenal ulcer: a case report and literature review.International journal of surgery case reports · 2026Article
- Perforated gastric schwannoma treated with laparoscopic wedge gastrectomy: a rare case report.International journal of surgery case reports · 2026Article
- Impact of acute cholangitis severity on the safety of laparoscopic common bile duct exploration with primary closure: a stratified retrospective study.Surgical endoscopy · 2026Article
- Global Burden of Peptic Ulcer Disease (1990-2021) and Projections to 2050: A Comprehensive Analysis of Age, Sex, and Socioeconomic Disparities.Current medical science · 2026Article
- Article
96 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
31 authors at 20 institutions in 12 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Background: Peptic ulcer disease is common with a lifetime prevalence in the general population of 5-10% and an incidence of 0.1-0.3% per year. Despite a sharp reduction in incidence and rates of hospital admission and mortality over the past 30 years, complications are still encountered in 10-20% of these patients. Peptic ulcer disease remains a significant healthcare problem, which can consume considerable financial resources. Management may involve various subspecialties including surgeons, gastroenterologists, and radiologists. Successful management of patients with complicated peptic ulcer (CPU) involves prompt recognition, resuscitation when required, appropriate antibiotic therapy, and timely surgical/radiological treatment. Methods: The present guidelines have been developed according to the GRADE methodology. To create these guidelines, a panel of experts was designed and charged by the board of the WSES to perform a systematic review of the available literature and to provide evidence-based statements with immediate practical application. All the statements were presented and discussed during the 5th WSES Congress, and for each statement, a consensus among the WSES panel of experts was reached. Conclusions: The population considered in these guidelines is adult patients with suspected complicated peptic ulcer disease. These guidelines present evidence-based international consensus statements on the management of complicated peptic ulcer from a collaboration of a panel of experts and are intended to improve the knowledge and the awareness of physicians around the world on this specific topic. We divided our work into the two main topics, bleeding and perforated peptic ulcer, and structured it into six main topics that cover the entire management process of patients with complicated peptic ulcer, from diagnosis at ED arrival to post-discharge antimicrobial therapy, to provide an up-to-date, easy-to-use tool that can help physicians and surgeons during the decision-making process.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.