Evidence map›Paper›PMID 31921291›Full record

ArticleFrontiers in genetics2019

Validation of a Novel, Sensitive, and Specific Urine-Based Test for Recurrence Surveillance of Patients With Non-Muscle-Invasive Bladder Cancer in a Comprehensive Multicenter Study.

Rui Batista, João Vinagre, Hugo Prazeres, Cristina Sampaio, Pedro Peralta, Paulo Conceição, Amílcar Sismeiro, Ricardo Leão, Andreia Gomes, Frederico Furriel and 24 more

Abstract read
In one paragraph

Article in Frontiers in genetics, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 53 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
53citing papers in PubMed, 2 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

53 citing papers in PubMed, 2 syntheses or guidelines pooled it.

  1. Guideline
  2. Pooled it
  3. Article
  4. Review
  5. Article
  6. Article
  7. Review
  8. Review
  9. Advances in the management of localized bladder cancers.Nature reviews. Clinical oncology · 2026
    Review
  10. Review
  11. Article
  12. Review
  13. Review
  14. The role of angiogenin in bladder cancer: where are we in 2025?International urology and nephrology · 2025
    Review
  15. Review
  16. Bladder cancer biomarkers.Exploration of targeted anti-tumor therapy · 2025
    Review
  17. Article
  18. Observational
  19. Article
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

34 authors.

Rui Batistai3S-Instituto de Investigação e Inovação em Saúde, Porto, Portugal.
João Vinagrei3S-Instituto de Investigação e Inovação em Saúde, Porto, Portugal.
Hugo Prazeresi3S-Instituto de Investigação e Inovação em Saúde, Porto, Portugal.
Cristina Sampaioi3S-Instituto de Investigação e Inovação em Saúde, Porto, Portugal.
Pedro PeraltaDepartment of Urology Service, Portuguese Institute of Oncology, Coimbra, Portugal.
Paulo ConceiçãoDepartment of Urology Service, Portuguese Institute of Oncology, Coimbra, Portugal.
Amílcar SismeiroDepartment of Urology Service, Portuguese Institute of Oncology, Coimbra, Portugal.
Ricardo LeãoDepartment of Urology, Hospital de Braga, Braga, Portugal.
Andreia GomesDepartment of Urology, Hospital de Braga, Braga, Portugal.
Frederico FurrielDepartment of Urology, Hospital CUF Coimbra, Coimbra, Portugal.
Carlos OliveiraDepartment of Urology, Hospital de Braga, Braga, Portugal.
João Nuno TorresDepartment of Urology, Hospital de Braga, Braga, Portugal.
Pedro EufrásioDepartment of Urology, Hospital CUF Coimbra, Coimbra, Portugal.
Paulo AzinhaisDepartment of Urology, Hospital CUF Coimbra, Coimbra, Portugal.
Fábio AlmeidaDepartment of Urology, Hospital Universitário Fernando Pessoa, Porto, Portugal.
Edwin Romero GonzalezDepartment of Urology, Hospital Zafra-Llerena, Badajoz, Spain.
Bohdan BidovanetsDepartment of Surgery, Ternopil Regional Oncology Center, Ternopil, Ukraine.
Thorsten EckeDepartment of Urology, Helios Hospital, Bad Saarow, Germany.
Pascal StinjsDepartment of Urology, St. Antonius Hospital, Nieuwegein, Netherlands.
Álvaro Serrano PascualServicio de Urología, Hospital Clínico San Carlos, Madrid, Spain.
Rabehi AbdelmalekIndependent Researcher, El-Eulma, Algeria.
Ainara VillafruelaDepartment of Urology, Hospital Universitario Donostia, San Sebastian, Spain.
Pastora Beardo-VillarDepartment of Urology, Hospital Universitario de Araba, Vitória, Spain.
Nuno FidalgoDepartment of Urology, Hospital Garcia de Horta, Lisbon, Portugal.
Hakan ÖztürkDepartment of Urology, Medicalpark Izmir Hospital, Izmir, Turkey.
Carmen Gonzalez-EnguitaDepartment of Urology, Hospital Universitario Fundacion Jiménez Díaz, Madrid, Spain.
Juan MonzoDepartment of Urology, Hospital Universitario Fundacion Jiménez Díaz, Madrid, Spain.
Tomé LopesDepartment of Urology, Hospital de Santa Maria, Lisbon, Portugal.
Mario Álvarez-MaestroDepartment of Urology, Hospital Universitário La Paz, Madrid, Spain.
Patricia Parra ServanDepartment of Urology, Hospital de Mérida, Badajoz, Spain.
Santiago Moreno Perez De La CruzDepartment of Urology, Hospital Don Benito-Villanueva, Badajoz, Spain.
Mario Pual Sanchez PerezDepartment of Urology, Hospital Universitário de Badajoz, Badajoz, Spain.
Valdemar Máximoi3S-Instituto de Investigação e Inovação em Saúde, Porto, Portugal.
Paula Soaresi3S-Instituto de Investigação e Inovação em Saúde, Porto, Portugal.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Bladder cancer (BC), the most frequent malignancy of the urinary system, is ranked the sixth most prevalent cancer worldwide. Of all newly diagnosed patients with BC, 70-75% will present disease confined to the mucosa or submucosa, the non-muscle-invasive BC (NMIBC) subtype. Of those, approximately 70% will recur after transurethral resection (TUR). Due to high rate of recurrence, patients are submitted to an intensive follow-up program maintained throughout many years, or even throughout life, resulting in an expensive follow-up, with cystoscopy being the most cost-effective procedure for NMIBC screening. Currently, the gold standard procedure for detection and follow-up of NMIBC is based on the association of cystoscopy and urine cytology. As cystoscopy is a very invasive approach, over the years, many different noninvasive assays (both based in serum and urine samples) have been developed in order to search genetic and protein alterations related to the development, progression, and recurrence of BC.

Indexed as

FGFR3 mutationnon-muscle invasive bladder cancerTERT promoter mutationurinary testUromonitor®

Identifiers

PMID31921291
PMCPMC6930177

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.