ArticleFrontiers in genetics2019
High-Dimensional Bayesian Network Inference From Systems Genetics Data Using Genetic Node Ordering.
Article in Frontiers in genetics, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.
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Who cites it
16 citing papers in PubMed.
- Local graph estimation with pathwise false discovery control.Nature communications · 2026Article
- Circulating causal protein networks linked to future risk of myocardial infarction.Nature communications · 2025Article
- Utilizing RNA-seq data in monotone iterative generalized linear model to elevate prior knowledge quality of the circRNA-miRNA-mRNA regulatory axis.BMC bioinformatics · 2025Article
- Minimum uncertainty as Bayesian network model selection principle.BMC bioinformatics · 2025Article
- A Network-Driven Framework for Enhancing Gene-Disease Association Studies in Coronary Artery Disease.ArXiv · 2025Article
- Changes in expression of VGF, SPECC1L, HLA-DRA and RANBP3L act with APOE E4 to alter risk for late onset Alzheimer's disease.Scientific reports · 2024Article
- Dynamic label-free analysis of SARS-CoV-2 infection reveals virus-induced subcellular remodeling.Nature communications · 2024Article
- Predicting the genetic component of gene expression using gene regulatory networks.Bioinformatics advances · 2024Article
- The Human Brainome: changes in expression of VGF, SPECC1L, HLA-DRA and RANBP3L act with APOE E4 to alter risk for late onset Alzheimer's disease.Research square · 2023Article
- A review of causal discovery methods for molecular network analysis.Molecular genetics & genomic medicine · 2022Review
- Bayesian networks elucidate complex genomic landscapes in cancer.Communications biology · 2022Article
- eQTLs as causal instruments for the reconstruction of hormone linked gene networks.Frontiers in endocrinology · 2022Review
- Synthetic data generation with probabilistic Bayesian Networks.Mathematical biosciences and engineering : MBE · 2021Article
- Genomic prediction and QTL mapping of root system architecture and above-ground agronomic traits in rice (Oryza sativa L.) with a multitrait index and Bayesian networks.G3 (Bethesda, Md.) · 2021Article
- Graphical analysis for phenome-wide causal discovery in genotyped population-scale biobanks.Nature communications · 2021Article
- High-Dimensional Bayesian Network Inference From Systems Genetics Data Using Genetic Node Ordering.Frontiers in genetics · 2019Article
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3 authors.
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Abstract
Studying the impact of genetic variation on gene regulatory networks is essential to understand the biological mechanisms by which genetic variation causes variation in phenotypes. Bayesian networks provide an elegant statistical approach for multi-trait genetic mapping and modelling causal trait relationships. However, inferring Bayesian gene networks from high-dimensional genetics and genomics data is challenging, because the number of possible networks scales super-exponentially with the number of nodes, and the computational cost of conventional Bayesian network inference methods quickly becomes prohibitive. We propose an alternative method to infer high-quality Bayesian gene networks that easily scales to thousands of genes. Our method first reconstructs a node ordering by conducting pairwise causal inference tests between genes, which then allows to infer a Bayesian network
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