Evidence map›Paper›PMID 31921199›Full record

ReviewFrontiers in immunology2019

The CD40-ATP-P2X

Carlos S Subauste

Open access · goldAbstract readReview
In one paragraph

Review in Frontiers in immunology, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers.

0numbers the graph read from it
0cells of the map it votes in
22citing papers in PubMed
2.4field-weighted citation impact, top 12% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

22 citing papers in PubMed, 34 citations in OpenAlex.

  1. Early-stage diabetic retinopathy: gut-metabolic triggers, immune-neurodegeneration, and interventions.Graefe's archive for clinical and experimental ophthalmology = Albrecht von Graefes Archiv fur klinische und experimentelle Ophthalmologie · 2025
    Review
  2. Role of P2X7R in Retinal Diseases: A Review.Immunity, inflammation and disease · 2025
    Review
  3. Article
  4. Article
  5. Review
  6. Review
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  13. Article
  14. Review
  15. Regulations of Retinal Inflammation: Focusing on Müller Glia.Frontiers in cell and developmental biology · 2022
    Review
  16. Review
  17. The innate immune system in diabetic retinopathy.Progress in retinal and eye research · 2021
    Review
  18. Review
  19. Article
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

1 author at 1 institution in 1 country.

Carlos S SubausteDivision of Infectious Diseases and HIV Medicine, Department of Medicine, Case Western Reserve University, Cleveland, OH, United States.
Case Western Reserve University · US

Funding

Autophagy and Ocular ToxoplasmosisR01EY018341 · NEI · CASE WESTERN RESERVE UNIVERSITY · PI SUBAUSTE, CARLOS S · 2009 to 2024
$5.0M
Regulation of retinopathiesR01EY019250 · NEI · CASE WESTERN RESERVE UNIVERSITY · PI SUBAUSTE, CARLOS S · 2010 to 2022
$3.7M
NEI NIH HHS R01 EY019250
6 · The paper itself

Abstract

Extracellular adenosine 5'-triphosphate (ATP) functions not only as a neurotransmitter but is also released by non-excitable cells and mediates cell-cell communication involving glia. In pathological conditions, extracellular ATP released by astrocytes may act as a "danger" signal that activates microglia and promotes neuroinflammation. This review summarizes

Indexed as

Adenosine TriphosphateAnimalsApoptosisCapillariesCD40 AntigensCell CommunicationEndothelial CellsHumansInflammationIschemiaMacrophagesMicrogliaReceptors, Purinergic P2X7Retinal DiseasesRetinal VesselsAdenosine TriphosphateCD40 AntigensP2RX7 protein, humanReceptors, Purinergic P2X7ATPCD40cytokinediabetesendothelial cellgliaretina

Identifiers

PMID31921199
PMCPMC6928124
OpenAlexW2993450133

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.