Evidence map›Paper›PMID 31921181›Full record

ArticleFrontiers in immunology2019

FOXO3 Transcription Factor Regulates IL-10 Expression in Mycobacteria-Infected Macrophages, Tuning Their Polarization and the Subsequent Adaptive Immune Response.

Rania Bouzeyen, Meriam Haoues, Mohamed-Ridha Barbouche, Ramandeep Singh, Makram Essafi

Open access · goldAbstract read
In one paragraph

Article in Frontiers in immunology, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 32 papers.

0numbers the graph read from it
0cells of the map it votes in
32citing papers in PubMed
1.8field-weighted citation impact, top 14% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

32 citing papers in PubMed, 49 citations in OpenAlex.

  1. Article
  2. Article
  3. Article
  4. Review
  5. Article
  6. Article
  7. Macrophage states and polarization duringFrontiers in cellular and infection microbiology · 2026
    Review
  8. Article
  9. Review
  10. Review
  11. The effect of TIM1Cell death & disease · 2025
    Article
  12. Article
  13. Review
  14. Article
  15. Article
  16. FOXO3: at the crossroads of metabolic, inflammatory, and tumorigenic remodeling in the colon.American journal of physiology. Gastrointestinal and liver physiology · 2024
    Review
  17. Abnormal Fetal Lung of Hoxa1Animals : an open access journal from MDPI · 2023
    Article
  18. Toxins · 2023
    Article
  19. mBio · 2023
    Article
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 3 institutions in 2 countries.

Rania BouzeyenLaboratory of Transmission, Control and Immunobiology of Infections (LTCII), Laboratoire de Recherche 11 (LR11), Institut Pasteur de Tunis (IPT), Tunis, Tunisia.
Meriam HaouesLaboratory of Transmission, Control and Immunobiology of Infections (LTCII), Laboratoire de Recherche 11 (LR11), Institut Pasteur de Tunis (IPT), Tunis, Tunisia.
Mohamed-Ridha BarboucheLaboratory of Transmission, Control and Immunobiology of Infections (LTCII), Laboratoire de Recherche 11 (LR11), Institut Pasteur de Tunis (IPT), Tunis, Tunisia.
Ramandeep SinghTuberculosis Research Laboratory, Translational Health Science and Technology Institute, NCR Biotech Science Cluster, Faridabad, India.
Makram EssafiLaboratory of Transmission, Control and Immunobiology of Infections (LTCII), Laboratoire de Recherche 11 (LR11), Institut Pasteur de Tunis (IPT), Tunis, Tunisia.
Institut Pasteur de Tunis · TNTunis El Manar University · TNTranslational Health Science and Technology Institute · IN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Alveolar Macrophages play a key role in the development of a robust adaptive immune response against the agent of Tuberculosis (TB),

Indexed as

Adaptive ImmunityCell LineForkhead Box Protein O3Gene Expression RegulationHumansInterleukin-10Macrophage ActivationMacrophagesModels, BiologicalMycobacterium tuberculosisPhosphatidylinositol 3-KinasesPromoter Regions, GeneticProto-Oncogene Proteins c-aktTuberculosisForkhead Box Protein O3FOXO3 protein, humanIL10 protein, humanInterleukin-10Phosphatidylinositol 3-KinasesProto-Oncogene Proteins c-aktFOXO3IL-10M1/Th1macrophagestuberculosis

Identifiers

PMID31921181
PMCPMC6927284
OpenAlexW3002223762

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.